The interfollicular epidermis of adult mouse tail comprises two distinct cell lineages that are differentially regulated by Wnt, Edaradd, and Lrig1.
The interfollicular epidermis of adult mouse tail comprises two distinct cell lineages that are differentially regulated by Wnt, Edaradd, and Lrig1.
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DOI：
10.1016/j.stemcr.2013.04.001
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发表时间：
2013
影响因子：
5.9
通讯作者：
Watt, Fiona M.
中科院分区：
文献类型：
--
作者：
Gomez, Celine;Chua, Wesley;Miremadi, Ahmad;Quist, Sven;Headon, Denis J.;Watt, Fiona M.
目前关于小鼠尾部毛囊间表皮（IFE）如何维持的模型忽略了两种不同的终末分化程序的共存：角化不全（鳞片）和正角化（鳞片间）。谱系追踪和克隆分析显示，鳞片和鳞片间由下方基底层的单能细胞维持，鳞片祖细胞比鳞片间祖细胞分裂更快。尽管鳞片有色素且与毛囊精确对齐，但黑素细胞和毛囊对于鳞片分化并非必需。表皮Wnt信号对于发育过程中鳞片的增大以及出生后鳞片 - 鳞片间边界的维持是必需的。Edaradd缺失抑制腹侧鳞片形成，而Lrig1缺失导致鳞片增大和融合。在野生型皮肤中，Lrig1在IFE中不表达，但在鳞片间下方的真皮成纤维细胞中选择性上调。我们得出结论，不同的IFE分化区域由不同的干细胞群体维持，并受表皮和真皮信号调节。
尾部毛囊间表皮包含两种不同的分化谱系
这些谱系由细胞周期时间不同的单能祖细胞维持
这些谱系独立于毛囊和黑素细胞
这些谱系受Wnt、Edaradd和Lrig1调节
Current models of how mouse tail interfollicular epidermis (IFE) is maintained overlook the coexistence of two distinct terminal differentiation programs: parakeratotic (scale) and orthokeratotic (interscale). Lineage tracing and clonal analysis revealed that scale and interscale are maintained by unipotent cells in the underlying basal layer, with scale progenitors dividing more rapidly than interscale progenitors. Although scales are pigmented and precisely aligned with hair follicles, melanocytes and follicles were not necessary for scale differentiation. Epidermal Wnt signaling was required for scale enlargement during development and for postnatal maintenance of scale-interscale boundaries. Loss of Edaradd inhibited ventral scale formation, whereas loss of Lrig1 led to scale enlargement and fusion. In wild-type skin, Lrig1 was not expressed in IFE but was selectively upregulated in dermal fibroblasts underlying the interscale. We conclude that the different IFE differentiation compartments are maintained by distinct stem cell populations and are regulated by epidermal and dermal signals. Tail interfollicular epidermis comprises two distinct differentiated lineages The lineages are maintained by unipotent progenitors that differ in cell-cycle time The lineages are independent of hair follicles and melanocytes The lineages are regulated by Wnt, Edaradd, and Lrig1
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