Clinical consequences of polypharmacy in elderly.

Clinical consequences of polypharmacy in elderly.
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DOI:
10.1517/14740338.2013.827660
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发表时间:
2014-01
影响因子:
3.1
通讯作者:
Hajjar ER
Hajjar ER
中科院分区:
医学3区
文献类型:
--
作者:
Maher RL;Hanlon J;Hajjar ER

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多重用药,定义为使用多种药物或超过医疗必要性,是一个越来越多的关注老年人。我们提供的信息; 1.)多种药物和不必要的药物使用的普遍性。(2)多药治疗的负面影响; 3.)改善多药治疗的干预措施。国际研究表明,多种药物在老年人中很常见,居住在养老院的人服用的药物数量最多。近50%的老年人服用一种或多种医疗上不必要的药物。研究已经清楚地建立了多种药物和不良临床后果之间的密切关系。此外,精心设计的跨专业(通常包括临床药剂师)干预研究,重点是招募高风险的老年患者与多种药物治疗表明,他们可以有效地提高整体质量的处方与混合结果的远端健康结果。
Polypharmacy, defined as the use of multiple drugs or more than are medically necessary, is a growing concern for older adults. We present information about; 1.) Prevalence of polypharmacy and unnecessary medication use. ; 2.) Negative Consequences of Polypharmacy; 3.) Interventions to improve polypharmacy. International research shows that polypharmacy is common in older adults with the highest number of drugs taken by those residing in nursing homes. Nearly 50% of older adults take one or more medications that are not medically necessary. Research has clearly established a strong relationship between polypharmacy and negative clinical consequences. Moreover, well designed inter-professional (often incuding clinical pharmacist) intervention studies that focus on enrolling high risk older patients with polypharmacy have shown that they can be effective in improving the overall quality of prescribing with mixed results on distal health outcomes.
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