Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep.
Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep.
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DOI：
10.1038/nature23663
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发表时间：
2017-08-31
期刊：
影响因子：
64.8
通讯作者：
Blackshaw S
中科院分区：
文献类型：
--
作者：
Liu K;Kim J;Kim DW;Zhang YS;Bao H;Denaxa M;Lim SA;Kim E;Liu C;Wickersham IR;Pachnis V;Hattar S;Song J;Brown SP;Blackshaw S
在哺乳动物中，已经发现了多个促进觉醒的神经元群体，但很少发现促进睡眠的神经元。促醒细胞类型包括下丘脑下部外侧的下丘脑泌素和GABA（γ-氨基丁酸）释放神经元，其促进从非快速眼动（NREM）和快速眼动（REM）睡眠向觉醒的过渡。在这里，我们表明，一个子集的GABA能神经元在小鼠腹侧海马，表达LIM同源域因子Lhx 6和睡眠压力激活，既直接抑制觉醒活性下丘脑和GABA能细胞在外侧下丘脑和接收输入多个睡眠-觉醒调节神经元。从发育中的间脑中有条件地删除Lhx 6会导致NREM和REM睡眠的减少。此外，选择性激活和抑制Lhx 6阳性神经元在腹侧海马双向调节成年小鼠的睡眠时间，部分通过下丘脑泌素依赖的机制。这些研究确定了促进睡眠的腹侧齿状回中的GABA能神经元亚群。
Multiple populations of wake-promoting neurons have been characterized in mammals, but few sleep-promoting neurons have been identified. Wake-promoting cell types include hypocretin and GABA (γ-aminobutyric-acid)-releasing neurons of the lateral hypothalamus, which promote the transition to wakefulness from non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Here we show that a subset of GABAergic neurons in the mouse ventral zona incerta, which express the LIM homeodomain factor Lhx6 and are activated by sleep pressure, both directly inhibit wake-active hypocretin and GABAergic cells in the lateral hypothalamus and receive inputs from multiple sleep–wake-regulating neurons. Conditional deletion of Lhx6 from the developing diencephalon leads to decreases in both NREM and REM sleep. Furthermore, selective activation and inhibition of Lhx6-positive neurons in the ventral zona incerta bidirectionally regulate sleep time in adult mice, in part through hypocretin-dependent mechanisms. These studies identify a GABAergic subpopulation of neurons in the ventral zona incerta that promote sleep.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
16.2
作者：
Li, Y;Gao, XB;van den Pol, AN
通讯作者：
van den Pol, AN
影响因子：
3.5
作者：
Saito YC;Tsujino N;Hasegawa E;Akashi K;Abe M;Mieda M;Sakimura K;Sakurai T
通讯作者：
Sakurai T
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
7.7
作者：
Liu J;Lee HJ;Weitz AJ;Fang Z;Lin P;Choy M;Fisher R;Pinskiy V;Tolpygo A;Mitra P;Schiff N;Lee JH
通讯作者：
Lee JH