A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping.
A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping.
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DOI：
10.1016/j.neuroimage.2012.01.124
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发表时间：
2012-07-16
期刊：
影响因子：
5.7
通讯作者：
Culver, Joseph P.
中科院分区：
文献类型：
--
作者：
Eggebrecht, Adam T.;White, Brian R.;Ferradal, Silvina L.;Chen, Chunxiao;Zhan, Yuxuan;Snyder, Abraham Z.;Dehghani, Hamid;Culver, Joseph P.
功能性神经影像学在当前神经科学研究中占据主导地位。然而，其在床边临床和某些神经科学研究中的使用受到限制，因为当前的工具缺乏非侵入性、非电离和便携式的组合，同时保持中等分辨率和定位精度。光学神经成像满足许多这些要求，但直到最近的进展，在高密度扩散光学断层扫描（HD-DOT），已受到限制的分辨率。虽然HD-DOT的早期结果很有希望，但缺乏HD-DOT与功能性磁共振成像（fMRI）金标准的定量体素比较和验证。在这里，我们提供了这样的分析在视觉皮层内使用匹配的视觉刺激协议在一组受试者（n=5）在单独的HD-DOT和功能磁共振成像扫描会话。为了实现HD-DOT和fMRI图像空间之间所需的体素到体素的配准，我们实现了特定于受试者的头部建模，其中包括MRI解剖结构、详细分割以及源和检测器位置的对齐。视觉反应的比较发现，HD-DOT和fMRI之间的平均定位误差为4.4 +/-1 mm，明显小于皮质回之间的平均距离。这种特异性表明，HD-DOT具有足够的图像质量，可用作fMRI的替代品。
Functional neuroimaging commands a dominant role in current neuroscience research. However its use in bedside clinical and certain neuro-scientific studies has been limited because the current tools lack the combination of being non-invasive, non-ionizing and portable while maintaining moderate resolution and localization accuracy. Optical neuroimaging satisfies many of these requirements, but, until recent advances in high-density diffuse optical tomography (HD-DOT), has been hampered by limited resolution. While early results of HD-DOT have been promising, a quantitative voxel-wise comparison and validation of HD-DOT against the gold standard of functional magnetic resonance imaging (fMRI) has been lacking. Herein, we provide such an analysis within the visual cortex using matched visual stimulation protocols in a single group of subjects (n=5) during separate HD-DOT and fMRI scanning sessions. To attain the needed voxel-to-voxel co-registration between HD-DOT and fMRI image spaces, we implemented subject-specific head modeling that incorporated MRI anatomy, detailed segmentation, and alignment of source and detector positions. Comparisons of the visual responses found an average localization error between HD-DOT and fMRI of 4.4 +/− 1 mm, significantly less than the average distance between cortical gyri. This specificity demonstrates that HD-DOT has sufficient image quality to be useful as a surrogate for fMRI.
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影响因子：
1.9
作者：
Dehghani H;White BR;Zeff BW;Tizzard A;Culver JP
通讯作者：
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通讯作者：
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