Pentachlorophenol and hydroxylated polychlorinated biphenyl metabolites in umbilical cord plasma of neonates from coastal populations in Québec.
Pentachlorophenol and hydroxylated polychlorinated biphenyl metabolites in umbilical cord plasma of neonates from coastal populations in Québec.
复制标题
DOI：
10.1289/ehp.02110411
复制
发表时间：
2002-04
影响因子：
10.4
通讯作者：
Norstrom RJ
中科院分区：
文献类型：
--
作者：
Sandau CD;Ayotte P;Dewailly E;Duffe J;Norstrom RJ
对魁北克省三个不同地区的脐带血浆样本中的多氯联苯 (PCB)、PCB 的羟基化代谢物 (HO-PCB) 和八氯苯乙烯 (4-HO-HpCS) 以及五氯苯酚 (PCP) 的浓度进行了测定。研究区域包括努纳维克（因纽特人）和圣劳伦斯湾下北岸（自给渔民）这两个因以海洋食品为主的饮食而接触多氯联苯较高的沿海地区，以及魁北克南部城市中心（魁北克市），其中多氯联苯接触量处于背景水平。所有地区的主要氯化酚类化合物是五氯苯酚。五氯苯酚浓度在各地区之间没有显着差异（几何平均浓度为 1,670 皮克/克，血浆湿重范围为 628-7,680 皮克/克）。五氯苯酚与多氯联苯同系物 153 (CB153) 浓度之比范围为 0.72 至 42.3。 HO-PCB 总浓度 (sigma HO-PCBs) 浓度因地区而异，下北岸、努纳维克和魁北克南部群体的几何平均浓度分别为 553（范围 238-1,750）、286（103-788）和 234（147-464）pg/g 湿重血浆。下北岸样本的总 PCB 几何平均浓度（49 种同源物的总和；西格玛 PCB）的几何平均浓度也最高，血浆湿重为 2,710 (525-7,720) pg/g。努纳维克样本和南部样本的西格玛 PCB 浓度分别为 1,510 (309-6,230) 和 843 (290-1,650) pg/g 湿重血浆。 sigma HO-PCB 和 sigma PCB 的浓度（对数转换）显着相关（r = 0.62，p < 0.001），所有主要个体 HO-PCB 同系物和个体 PCB 同系物的浓度也是如此。在努纳维克和下北岸样品中，游离甲状腺素 (T4) 浓度（对数转换）与定量的氯化酚类化合物总和（PCP 和 sigma HO-PCB 总和；r = -0.47，p = 0.01，n = 20）呈负相关，并且与任何 PCB 同系物或 sigma PCB 不相关。这表明 PCP 和 HO-PCB 可能会改变新生儿的甲状腺激素状态，从而导致婴儿的神经发育影响。需要进一步的研究来检查氯化酚类化合物对新生儿甲状腺激素状态的影响。
Concentrations of polychlorinated biphenyls (PCBs), hydroxylated metabolites of PCBs (HO-PCBs) and octachlorostyrene (4-HO-HpCS), and pentachlorophenol (PCP) were determined in umbilical cord plasma samples from three different regions of Québec. The regions studied included two coastal areas where exposure to PCBs is high because of marine-food-based diets--Nunavik (Inuit people) and the Lower North Shore of the Gulf of St. Lawrence (subsistence fishermen)--and a southern Québec urban center where PCB exposure is at background levels (Québec City). The main chlorinated phenolic compound in all regions was PCP. Concentrations of PCP were not significantly different among regions (geometric mean concentration 1,670 pg/g, range 628-7,680 pg/g wet weight in plasma). The ratio of PCP to polychlorinated biphenyl congener number 153 (CB153) concentration ranged from 0.72 to 42.3. Sum HO-PCB (sigma HO-PCBs) concentrations were different among regions, with geometric mean concentrations of 553 (range 238-1,750), 286 (103-788), and 234 (147-464) pg/g wet weight plasma for the Lower North Shore, Nunavik, and the southern Québec groups, respectively. Lower North Shore samples also had the highest geometric mean concentration of sum PCBs (sum of 49 congeners; sigma PCBs), 2,710 (525-7,720) pg/g wet weight plasma. sigma PCB concentrations for Nunavik samples and southern samples were 1,510 (309-6,230) and 843 (290-1,650) pg/g wet weight plasma. Concentrations (log transformed) of sigma HO-PCBs and sigma PCBs were significantly correlated (r = 0.62, p < 0.001), as were concentrations of all major individual HO-PCB congeners and individual PCB congeners. In Nunavik and Lower North Shore samples, free thyroxine (T4) concentrations (log transformed) were negatively correlated with the sum of quantitated chlorinated phenolic compounds (sum PCP and sigma HO-PCBs; r = -0.47, p = 0.01, n = 20) and were not correlated with any PCB congeners or sigma PCBs. This suggests that PCP and HO-PCBs are possibly altering thyroid hormone status in newborns, which could lead to neurodevelopmental effects in infants. Further studies are needed to examine the effects of chlorinated phenolic compounds on thyroid hormone status in newborns.
登录
查看更多内容
影响因子：
4.8
作者：
Kester, MHA;Bulduk, S;Visser, TJ
通讯作者：
Visser, TJ
影响因子：
2.5
作者：
HUISMAN, M;KOOPMANESSEBOOM, C;BOERSMA, ER
通讯作者：
BOERSMA, ER
影响因子：
4.6
作者：
JACOBSON, SW;FEIN, GG;DOWLER, JK
通讯作者：
DOWLER, JK
影响因子：
8.8
作者：
DEWAILLY, E;LALIBERTE, C;AYOTTE, P
通讯作者：
AYOTTE, P
影响因子：
10.4
作者：
Fielden MR;Chen I;Chittim B;Safe SH;Zacharewski TR
通讯作者：
Zacharewski TR