Analysis of AVPR1A, thermal and pressure pain thresholds, and stress in sickle cell disease.
Analysis of AVPR1A, thermal and pressure pain thresholds, and stress in sickle cell disease.
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DOI：
10.3389/fpain.2022.1060245
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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在镰状细胞病（SCD）患者中，强烈的慢性和急性疼痛发作会导致负面的身体和情绪体验，但这些因素及其相互作用尚未得到很好的理解。精氨酸加压素受体1a基因（AVPR 1A）单核苷酸多态性rs 10877969先前已与急性疼痛和应激相关疼痛相关。在这项研究中，我们测试了这个SNP，热和压力疼痛阈值，临床疼痛和SCD患者的压力之间的关联。150名入选SCD的成人完成了疼痛强度测量（平均疼痛强度，API）和感知压力问卷（PSQ）。从定量感觉测试（QST）中获得热和压力痛阈值数据，并获得rs 10877969基因型。在调整了年龄和性别的模型中，在rs 10877969基因型之间，我们观察到热（冷，p = 0.66;热，p = 0.91）和机械（压力，p = 0.33）疼痛阈值没有显著差异。rs 10877969与API（p = 0.09）的相关性处于临界状态，但与PSQ（p = 0.51）的相关性不显著。临床疼痛与环境应激有显著相关（r = 0.18，p = 0.024），而基因型与PSQ的交互作用不显著（p = 0.63）。临床和实验性疼痛与rs 10877969基因型无显著相关性。rs 10877969基因型并没有缓和环境压力和临床疼痛之间的相关性，在这个人群中。然而，一个趋势，以保护T等位基因效应的平均疼痛评级在SCD值得未来的探索，这种SNP/基因在SCD。
In patients with sickle cell disease (SCD), negative physical and emotional experiences result from intense chronic and acute pain episodes, but factors underlying these, and their interactions, are not well understood. The arginine vasopressin receptor 1a gene (AVPR1A) single nucleotide polymorphism rs10877969 has been previously associated with aspects of acute pain and stress related pain. In this study, we tested for associations between this SNP, thermal and pressure pain thresholds, clinical pain, and stress in people with SCD. 150 adults enrolled with SCD completed pain intensity measures (Average Pain Intensity, API) and the Perceived Stress Questionnaire (PSQ). Thermal and pressure pain threshold data were available from quantitative sensory testing (QST), and rs10877969 genotypes were obtained. In models adjusted for age and gender, between rs10877969 genotypes, we observed no significant differences in thermal (cold, p = 0.66; heat, p = 0.91) and mechanical (pressure, p = 0.33) pain thresholds. The association of rs10877969 with API (p = 0.09) was borderline, but non-significant with PSQ (p = 0.51). The correlation between clinical pain and environmental stress was significant, r = 0.18, p = 0.024, however, the interaction of genotype and PSQ was not significant (p = 0.63). Clinical and experimental pain were not significantly associated with the rs10877969 genotype. The rs10877969 genotype did not moderate the correlation between environmental stress and clinical pain in this population. However, a trend toward a protective T allele effect on average pain rating in SCD warrants future exploration of this SNP/gene in SCD.
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影响因子：
7.4
作者：
Campbell, CM;Edward, RR;Fillingim, RB
通讯作者：
Fillingim, RB
DOI：
10.1097/mph.0000000000000214
发表时间：
2015-04
期刊：
Journal of pediatric hematology/oncology
影响因子：
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作者：
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通讯作者：
Sethna NF
DOI：
10.1097/ncn.0b013e3181d7820b
发表时间：
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期刊：
Computers, informatics, nursing : CIN
影响因子：
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作者：
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通讯作者：
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影响因子：
4
作者：
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通讯作者：
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影响因子：
4.2
作者：
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通讯作者：
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