Candida albicans exploits N-acetylglucosamine as a gut signal to establish the balance between commensalism and pathogenesis.
Candida albicans exploits N-acetylglucosamine as a gut signal to establish the balance between commensalism and pathogenesis.
复制标题
DOI：
10.1038/s41467-023-39284-w
复制
发表时间：
2023-06-26
影响因子：
16.6
通讯作者：
Lu, Yang
中科院分区：
文献类型：
--
作者：
Yang, Dandan;Zhang, Mao;Su, Chang;Dong, Bin;Lu, Yang
白色念珠菌是肠道微生物区系中的一种良性成员，但也会引起威胁生命的播散性感染，这表明这种真菌的共生关系是随着毒力特征的保留而进化的。在这里，我们揭示了N-乙酰氨基葡萄糖(GlcNAc)使白色念珠菌能够在共生和致病之间取得平衡。虽然GlcNAc分解代谢有利于白色念珠菌的共生生长，但删除GlcNAc传感器转导Ngs1可以增强适应性，表明GlcNAc信号不利于共生。有趣的是，添加GlcNAc会减弱肠道进化的白色念珠菌的共生适合度，但保留了其致病潜力。我们进一步证明GlcNAc是肠道菌丝相关转录的主要诱导者，这代表了共生-致病平衡的关键决定因素。除了酵母到菌丝的形态发生，我们还确定了其他因素，包括Sod5和Ofi1，有助于平衡。因此，白色念珠菌使用GlcNAc在支持共生和毒力的真菌程序之间建立权衡，这可能解释了它作为共生和病原体的成功。机会性病原体在共生性和致病机制之间转换的机制仍然知之甚少。在这里，作者表明，N-乙酰氨基葡萄糖，一种富含在肠道中的碳源，在调节白色念珠菌的共生-致病平衡方面发挥了作用。
Candida albicans is a benign member of gut microbiota, but also causes life-threatening disseminated infections, suggesting that this fungus commensalism has evolved with retention of virulence traits. Here we reveal that N-acetylglucosamine (GlcNAc) enables C. albicans to balance between commensalism and pathogenesis. Although GlcNAc catabolism is beneficial for commensal growth of C. albicans, deleting GlcNAc sensor-transducer Ngs1 confers enhanced fitness, indicating that GlcNAc signaling is detrimental to commensalism. Interestingly, addition of GlcNAc attenuates commensal fitness of gut-evolved C. albicans but retains its disease-causing potential. We further demonstrate that GlcNAc is a major inducer of hypha-associated transcription in the gut, which represents the key determinant for commensal-pathogenic equilibrium. In addition to yeast-to-hypha morphogenesis, we also identify other factors, including Sod5 and Ofi1, that contribute to the balance. Thus, C. albicans uses GlcNAc to build up a tradeoff between fungal programs supporting commensalism and virulence, which may explain its success as a commensal and pathogen. The mechanisms by which opportunistic pathogens shift between commensalism and pathogenesis remains poorly understood. Here, the authors show that N-acetylglucosamine, a carbon source enriched in the gut, plays a role in modulating commensal-pathogenic balance in Candida albicans.
登录
查看更多内容
影响因子：
64.5
作者：
Lo, HJ;Kohler, JR;Fink, GR
通讯作者：
Fink, GR
影响因子：
3.3
作者：
Naseem, Shamoon;Min, Kyunghun;Konopka, James B.
通讯作者：
Konopka, James B.
影响因子：
64.8
作者：
Moyes DL;Wilson D;Richardson JP;Mogavero S;Tang SX;Wernecke J;Höfs S;Gratacap RL;Robbins J;Runglall M;Murciano C;Blagojevic M;Thavaraj S;Förster TM;Hebecker B;Kasper L;Vizcay G;Iancu SI;Kichik N;Häder A;Kurzai O;Luo T;Krüger T;Kniemeyer O;Cota E;Bader O;Wheeler RT;Gutsmann T;Hube B;Naglik JR
通讯作者：
Naglik JR
DOI：
10.3390/jof3040057
发表时间：
2017-10-18
期刊：
Journal of fungi (Basel, Switzerland)
影响因子：
--
作者：
Bongomin F;Gago S;Oladele RO;Denning DW
通讯作者：
Denning DW
N-乙酰氨基葡萄糖诱导的白色念珠菌细胞死亡及其对酵母营养感应适应性机制的影响。
影响因子：
6.4
作者：
Du H;Guan G;Li X;Gulati M;Tao L;Cao C;Johnson AD;Nobile CJ;Huang G
通讯作者：
Huang G