Evaluation of Regional Lung Function in Pulmonary Fibrosis with Xenon-129 MRI.
Evaluation of Regional Lung Function in Pulmonary Fibrosis with Xenon-129 MRI.
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DOI：
10.3390/tomography7030039
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发表时间：
2021-09-15
期刊：
影响因子：
--
通讯作者：
Mehrad B
中科院分区：
文献类型：
--
作者：
Mata J;Guan S;Qing K;Tustison N;Shim Y;Mugler JP 3rd;Altes T;Huaromo J;Mehrad B
特发性肺纤维化是间质性肺疾病的一种类型，其进展在临床上往往是不可预测的。本文介绍了超极化Xenon-129化学位移成像作为一种无创、无放射性的探测肺生理和解剖的方法，以监测IPF受试者的细微变化。20例受试者，其中9例健康体检者和11例IPF受试者，接受了HP Xe-129机械通气MRI和3D-SBCSI检查。所有受试者在成像前进行肺活量测定，并在成像后测量IPF受试者的DLCO和红细胞压积。图像在MatLab中进行后处理，并使用蚂蚁算法进行分割。与健康受试者相比，IPF受试者平均表现出更高的组织/气体比和更低的RBC/气体比，定量图谱在IPF受试者中更具异质性。较高的比例可能是由于肺间质纤维化和增厚。T2*松弛在IPF受试者中较长，并与红细胞压积分数相对应，尽管其机制尚不清楚。红细胞光谱峰的较低化学位移与较高的组织/红细胞比率有很好的相关性，这可能是由于血液含氧量减少所致。组织/RBC在空间上也与HRCT图像中的纤维化区域有很好的相关性。这些结果可能有助于我们理解气体交换障碍和疾病进展背后的潜在机制。
Idiopathic pulmonary fibrosis, a pattern of interstitial lung disease, is often clinically unpredictable in its progression. This paper presents hyperpolarized Xenon-129 chemical shift imaging as a noninvasive, nonradioactive method of probing lung physiology as well as anatomy to monitor subtle changes in subjects with IPF. Twenty subjects, nine healthy and eleven IPF, underwent HP Xe-129 ventilation MRI and 3D-SBCSI. Spirometry was performed on all subjects before imaging, and DLCO and hematocrit were measured in IPF subjects after imaging. Images were post-processed in MATLAB and segmented using ANTs. IPF subjects exhibited, on average, higher Tissue/Gas ratios and lower RBC/Gas ratios compared with healthy subjects, and quantitative maps were more heterogeneous in IPF subjects. The higher ratios are likely due to fibrosis and thickening of the pulmonary interstitium. T2* relaxation was longer in IPF subjects and corresponded with hematocrit scores, although the mechanism is not well understood. A lower chemical shift in the red blood cell spectroscopic peak correlated well with a higher Tissue/RBC ratio and may be explained by reduced blood oxygenation. Tissue/RBC also correlated well, spatially, with areas of fibrosis in HRCT images. These results may help us understand the underlying mechanism behind gas exchange impairment and disease progression.
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影响因子：
4.4
作者：
Mugler, John P.;Altes, Talissa A.
通讯作者：
Altes, Talissa A.
影响因子：
3.3
作者：
Norquay G;Leung G;Stewart NJ;Wolber J;Wild JM
通讯作者：
Wild JM
DOI：
10.1183/09059180.00008613
发表时间：
2014-03-01
期刊：
European respiratory review : an official journal of the European Respiratory Society
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1006/jmrb.1996.0098
发表时间：
1996-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Sakai, K;Bilek, AM;Albert, MS
通讯作者：
Albert, MS
影响因子：
3.9
作者：
Barratt SL;Creamer A;Hayton C;Chaudhuri N
通讯作者：
Chaudhuri N