Hyperpolarized 129Xe MRI of the human lung.
Hyperpolarized 129Xe MRI of the human lung.
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DOI：
10.1002/jmri.23844
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发表时间：
2013-02
影响因子：
4.4
通讯作者：
Altes, Talissa A.
中科院分区：
文献类型：
--
作者：
Mugler, John P.;Altes, Talissa A.
通过允许肺的气隙的直接可视化，使用超极化气体的MR成像提供了评估肺结构和功能的独特策略。虽然绝大多数的人类研究都是使用超极化的3He进行的，但最近3He供应的收缩和随之而来的价格上涨已经将注意力转向了替代剂，超极化的129 He。与3He相比，129 He由于其较小的磁矩而产生较低的信号。尽管如此，利用气体极化技术的进步，最近在人体中使用测量通气、扩散和氧分压的技术进行的研究表明，超极化129 He的结果与以前使用超极化3He的结果相当。此外，氙具有在吸入后容易溶解在肺组织和血液中的优点，这使得超极化129对于探索肺功能的某些特征特别有吸引力，例如气体交换和摄取，这是使用3He无法获得的。溶解在人肺中的129氚成像方法的初步结果表明，这些方法将为量化气体输送、交换和运输之间的关系提供新的机会，从而显示出扩大我们对肺部疾病的理解的巨大潜力。最后，超极化气田商业前景的最新变化现在使这项创新技术有可能超越研究实验室。
By permitting direct visualization of the airspaces of the lung, MR imaging using hyperpolarized gases provides unique strategies for evaluating pulmonary structure and function. Although the vast majority of research in humans has been performed using hyperpolarized 3He, recent contraction in the supply of 3He and consequent increases in price have turned attention to the alternative agent, hyperpolarized 129Xe. Compared to 3He, 129Xe yields reduced signal due to its smaller magnetic moment. Nonetheless, taking advantage of advances in gas-polarization technology, recent studies in humans using techniques for measuring ventilation, diffusion, and partial pressure of oxygen have demonstrated results for hyperpolarized 129Xe comparable to those previously demonstrated using hyperpolarized 3He. In addition, xenon has the advantage of readily dissolving in lung tissue and blood following inhalation, which makes hyperpolarized 129Xe particularly attractive for exploring certain characteristics of lung function, such as gas exchange and uptake, which cannot be accessed using 3He. Preliminary results from methods for imaging 129Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden our understanding of lung disease. Finally, recent changes in the commercial landscape of the hyperpolarized-gas field now make it possible for this innovative technology to move beyond the research lab.
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影响因子：
7.3
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
4.4
作者：
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通讯作者：
Brookeman, JR