Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis.
Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis.
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骨骼-脉管系统链式反应：对稳态之谜的新见解
DOI：
10.1038/s41413-021-00138-0
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发表时间：
2021-03-22
期刊：
影响因子：
12.7
通讯作者：
Tang P
中科院分区：
文献类型：
--
作者：
Chen M;Li Y;Huang X;Gu Y;Li S;Yin P;Zhang L;Tang P
血管生成和骨生成是耦合的。然而，这些过程的细胞和分子调控仍有待进一步研究。这两种组织最近被认为是内分泌器官，这激发了研究兴趣，在筛选和功能鉴定的新的旁分泌因子从这两种组织。本文旨在阐述骨与血管系统之间的内分泌调节环的新奇和意义。此外，还对骨血管、血管相关性骨骼疾病、病理状态以及血管生成靶向治疗策略的研究进展进行了综述。关于未来的前景，新技术，如单细胞测序，它可以用来显示细胞的多样性和可塑性的两种组织，正在促进这一领域的进展。此外，细胞外囊泡介导的核酸通讯值得进一步研究。总之，对血管生成和成骨偶联的细胞和分子调节的更深入的理解可能提供识别新的治疗靶点的机会。
Angiogenesis and osteogenesis are coupled. However, the cellular and molecular regulation of these processes remains to be further investigated. Both tissues have recently been recognized as endocrine organs, which has stimulated research interest in the screening and functional identification of novel paracrine factors from both tissues. This review aims to elaborate on the novelty and significance of endocrine regulatory loops between bone and the vasculature. In addition, research progress related to the bone vasculature, vessel-related skeletal diseases, pathological conditions, and angiogenesis-targeted therapeutic strategies are also summarized. With respect to future perspectives, new techniques such as single-cell sequencing, which can be used to show the cellular diversity and plasticity of both tissues, are facilitating progress in this field. Moreover, extracellular vesicle-mediated nuclear acid communication deserves further investigation. In conclusion, a deeper understanding of the cellular and molecular regulation of angiogenesis and osteogenesis coupling may offer an opportunity to identify new therapeutic targets.
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影响因子：
20.3
作者：
Cackowski, Frank C.;Anderson, Judith L.;Roodman, G. David
通讯作者：
Roodman, G. David
影响因子：
4.8
作者：
Canalis, Ernesto;Brunet, Lisa J.;Zanotti, Stefano
通讯作者：
Zanotti, Stefano
Lipocalin-2/ngal作为炎症和代谢疾病的生物标志物的潜力。
DOI：
10.3109/1354750x.2015.1123354
发表时间：
2015
期刊：
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
影响因子：
--
作者：
Abella V;Scotece M;Conde J;Gómez R;Lois A;Pino J;Gómez-Reino JJ;Lago F;Mobasheri A;Gualillo O
通讯作者：
Gualillo O
DOI：
10.1007/978-1-4939-6448-2_1
发表时间：
2017
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Alto LT;Terman JR
通讯作者：
Terman JR
影响因子：
10.9
作者：
Blackwell, Katherine A.;Raisz, Lawrence G.;Pilbeam, Carol C.
通讯作者：
Pilbeam, Carol C.