Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women.
Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women.
复制标题
DOI：
10.1002/oby.20247
复制
发表时间：
2013-01
期刊：
影响因子：
6.9
通讯作者：
Kanaley, Jill A.
中科院分区：
文献类型：
--
作者：
Heden, Timothy D.;Liu, Ying;Sims, Lauren J.;Whaley-Connell, Adam T.;Chockalingam, Anand;Dellsperger, Kevin C.;Kanaley, Jill A.
本研究的目的是比较肥胖女性三餐和六餐等热量高碳水化合物膳食频率模式的餐后血脂、氧化应激、抗氧化活性和胰岛素血症。在平衡顺序中，八名肥胖女性完成了两个为期 12 小时的条件，其中她们消耗 1500 卡路里（14% 蛋白质、21% 脂肪和 65% 碳水化合物），或者每 4 小时吃三顿 500 卡路里流质餐，或者每 2 小时吃六顿 250 卡路里流质餐。每 30 分钟采集一次血样，并分析三酰甘油 (TAG)、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、氧化低密度脂蛋白胆固醇、髓过氧化物酶、对氧磷酶 1 活性和胰岛素。与六餐条件（481±155 mg/dL·12 h）相比，三餐条件下的TAG增量曲线下面积（iAUC）（321±129 mg/dL·12 h）显着较低（P = 0.04）。三餐条件下的胰岛素 iAUC (5,549 ± 1,007 pmol/L·12 h) 显着高于六餐条件 (4,230 ± 757 pmol/L·12 h) (P = 0.05)。进餐频率对其他生化变量没有影响。总的来说，三顿和六顿等热量的高碳水化合物膳食频率模式会差异性地改变肥胖女性的餐后 TAG 和胰岛素浓度，但对餐后胆固醇、氧化应激或抗氧化活性没有影响。
The aim of this study was to compare postprandial lipemia, oxidative stress, antioxidant activity, and insulinemia between a three and six isocaloric high carbohydrate meal frequency pattern in obese women. In a counterbalanced order eight obese women completed two, 12 h conditions in which they consumed 1500 calories (14% protein, 21% fat, and 65% carbohydrate) either as three 500 calorie liquid meals every 4 h or six 250 calorie liquid meals every 2 h. Blood samples were taken every 30 min and analyzed for triacylglycerol (TAG), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, oxidized low-density lipoprotein cholesterol, myeloperoxidase, paraoxonase-1 activity, and insulin. The TAG incremental area under the curve (iAUC) during the three meal condition (321 ± 129 mg/dL·12 h) was significantly lower (P = 0.04) compared to the six meal condition (481 ± 155 mg/dL·12 h). The insulin iAUC during the three meal condition (5,549 ± 1,007 pmol/L·12 h) was significantly higher (P = 0.05) compared to the six meal condition (4,230 ± 757 pmol/L·12 h). Meal frequency had no influence on the other biochemical variables. Collectively, a three and six isocaloric high carbohydrate meal frequency pattern differentially alters postprandial TAG and insulin concentrations but has no effect on postprandial cholesterol, oxidative stress, or antioxidant activity in obese women.
登录
查看更多内容
影响因子：
3.7
作者：
Pruessner, JC;Kirschbaum, C;Hellhammer, DH
通讯作者：
Hellhammer, DH
DOI：
10.1016/j.numecd.2005.09.005
发表时间：
2006-10-01
影响因子：
3.9
作者：
Beer, Sandra;Moren, Xenia;James, Richard W.
通讯作者：
James, Richard W.
影响因子：
15.9
作者：
Podrez, EA;Schmitt, D;Hazen, SL
通讯作者：
Hazen, SL
影响因子：
3.2
作者：
Hajer, Gideon R.;Dallinga-Thie, Geesje M.;Visseren, Frank L. J.
通讯作者：
Visseren, Frank L. J.
影响因子：
7.1
作者：
JONES, PJH;LEITCH, CA;PEDERSON, RA
通讯作者：
PEDERSON, RA