A cluster of specified microRNAs in peripheral blood as biomarkers for metastatic non-small-cell lung cancer by stem-loop RT-PCR.
A cluster of specified microRNAs in peripheral blood as biomarkers for metastatic non-small-cell lung cancer by stem-loop RT-PCR.
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DOI：
10.1007/s00432-011-1068-z
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发表时间：
2012-01
影响因子：
3.6
通讯作者：
Shen, Dong
中科院分区：
文献类型：
--
作者：
Lin, Qingfeng;Mao, Weidong;Shu, Yongqian;Lin, Feng;Liu, Shaoping;Shen, Hua;Gao, Wen;Li, Suqing;Shen, Dong
研究人外周血中一些特定的microrna的水平，以确定它们是否可以作为转移性非小细胞肺癌的生物标志物。使用定量茎环RT-PCR方法检测来自IV期、I/II期非小细胞肺癌患者和对照组的某些microrna的血清水平，包括has-miR-125a-5p、has-miR-126、has-miR-183、has-miR-200、has-miR-221和has-miR-222。hsa-miR-126、hsa-miR-183和hsa-miR-222的血清水平在对照组和IV期患者之间有统计学差异，但has-miR-125a-5p、has-miR-200和has-miR-221的血清水平无统计学差异。hsa-miR-126和hsa-miR-183在I/II期患者和IV期患者之间也有统计学差异，但在对照组和I/II期患者之间无统计学差异。Hsa-miR-126和hsa-miR-183可能作为转移性非小细胞肺癌的潜在血清生物标志物。
To investigate the levels for some specified microRNAs in human’s peripheral blood so as to determine whether they can serve as biomarkers for metastatic non-small-cell lung cancer. Use a quantitative stem-loop RT-PCR method to examine the serum levels for certain microRNAs including has-miR-125a-5p, has-miR-126, has-miR-183, has-miR-200, has-miR-221, and has-miR-222 from the patients with Stage IV, Stage I/II non-small-cell lung cancer and the controls. There was statistical difference in the serum levels for hsa-miR-126, hsa-miR-183, and hsa-miR-222 between the controls and the Stage IV patients, but not for has-miR-125a-5p, has-miR-200 and has-miR-221. It also showed statistical difference for hsa-miR-126 and hsa-miR-183 between the Stage I/II patients and Stage IV patients, but not between the controls and Stage I/II patients. Hsa-miR-126 and hsa-miR-183 may serve as potential serum biomarkers for metastatic non-small-cell lung cancer.
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影响因子：
4.7
作者：
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DOI：
10.1111/j.1742-4658.2009.07238.x
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