Amyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure.
Amyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure.
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DOI：
10.1155/2008/562985
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发表时间：
2008
影响因子：
--
通讯作者：
Westermark P
中科院分区：
文献类型：
--
作者：
Andersson A;Bohman S;Borg LA;Paulsson JF;Schultz SW;Westermark GT;Westermark P
继埃德蒙顿小组令人鼓舞的报告之后，胰岛移植领域出现了复兴。在那之后，当临床结果的长期结果发表时，更悲观的观点传播开来。β细胞功能的进行性丧失意味着几乎所有患者在5年后重新接受胰岛素治疗。10多年前，我们证明了当移植到裸鼠体内时，淀粉样蛋白沉积物在人胰岛和转人IAPP基因的小鼠胰岛中迅速形成。因此，可以认为淀粉样蛋白形成是长期失败的一个潜在候选者。本文综述了我们实验室的尝试，以阐明移植胰岛中淀粉样蛋白形成的动力学和机制，特别强调长期高血糖的影响。
Following the encouraging report of the Edmonton group, there was a rejuvenation of the islet transplantation field. After that, more pessimistic views spread when long-term results of the clinical outcome were published. A progressive loss of the β-cell function meant that almost all patients were back on insulin therapy after 5 years. More than 10 years ago, we demonstrated that amyloid deposits rapidly formed in human islets and in mouse islets transgenic for human IAPP when grafted into nude mice. It is, therefore, conceivable to consider amyloid formation as one potential candidate for the long-term failure. The present paper reviews attempts in our laboratories to elucidate the dynamics of and mechanisms behind the formation of amyloid in transplanted islets with special emphasis on the impact of long-term hyperglycemia.
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影响因子：
3.5
作者：
BETSHOLTZ, C;CHRISTMANSSON, L;WESTERMARK, P
通讯作者：
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