Genetic diversity and distribution dynamics of multidrug-resistant Mycobacterium tuberculosis isolates in Nepal.
Genetic diversity and distribution dynamics of multidrug-resistant Mycobacterium tuberculosis isolates in Nepal.
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DOI：
10.1038/s41598-018-34306-w
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发表时间：
2018-11-09
影响因子：
4.6
通讯作者：
Suzuki Y
中科院分区：
文献类型：
--
作者：
Maharjan B;Nakajima C;Isoda N;Thapa J;Poudel A;Shah Y;Yamaguchi T;Shrestha B;Hoffmann H;Avsar K;Shrestha A;Gordon SV;Suzuki Y
耐多药结核病（MDR-TB）是尼泊尔新出现的公共卫生问题。尽管尼泊尔成功实施了结核病控制计划，但耐多药结核病的通报仍在增加，但原因尚不清楚。本研究的目的是了解尼泊尔耐多药结核分枝杆菌 (MTB) 分离株的遗传多样性和流行病学特征。我们对 2009 年 4 月至 2013 年 3 月收集的 498 株 MDR-MTB 菌株进行了分离和基因分型，并分析了患者的背景信息。我们的结果显示，谱系2（北京家族）是最主要的谱系（n = 241；48.4%），其次是谱系3（n = 153，30.7%）。谱系 4 是第三常见的（n = 73，14.5%），其次是谱系 1（n = 32，6.4%）。谱系与患者的地理区域、种族、年龄和性别显着相关。北京基因型被发现在尼泊尔耐多药结核病传播中发挥重要作用，并与东部地区、蒙古族和年轻群体显着相关。我们的结论是，早期诊断和治疗，包括耐多药结核病病例的分子流行病学监测，将有助于控制耐多药结核病在尼泊尔的传播。
Multidrug-resistant tuberculosis (MDR-TB) is an emerging public health problem in Nepal. Despite the implementation of a successful TB control program in Nepal, notifications of MDR-TB are increasing, yet the reasons are unknown. The objective of this study was to understand the genetic diversity and epidemiological characteristics of MDR-Mycobacterium tuberculosis (MTB) isolates in Nepal. We isolated and genotyped 498 MDR-MTB isolates collected from April 2009 to March 2013 and analyzed the patients’ background information. Our results showed that the lineage 2 (Beijing family) was the most predominant lineage (n = 241; 48.4%), followed by lineage 3 (n = 153, 30.7%). Lineage 4 was the third most prevalent (n = 73, 14.5%) followed by lineage 1 (n = 32, 6.4%). The lineages were significantly associated with geographic region, ethnic group, age and sex of patients. The Beijing genotype was found to have an important role in transmitting MDR-TB in Nepal and was significantly associated with the eastern region, mongoloid ethnic group and younger age group. We conclude that early diagnosis and treatment including molecular-epidemiological surveillance of MDR-TB cases will help to control transmission of MDR-TB in Nepal.
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影响因子：
3.7
作者：
Malla B;Stucki D;Borrell S;Feldmann J;Maharjan B;Shrestha B;Fenner L;Gagneux S
通讯作者：
Gagneux S
影响因子：
4.6
作者：
Liu Y;Jiang X;Li W;Zhang X;Wang W;Li C
通讯作者：
Li C
东亚南部起源以及结核分枝杆菌北京家族与汉族人的共同扩张。
DOI：
10.1073/pnas.1424063112
发表时间：
2015-06-30
影响因子：
11.1
作者：
Luo, Tao;Comas, Inaki;Gao, Qian
通讯作者：
Gao, Qian
影响因子：
--
作者：
Nikolayevskyy V;Balabanova Y;Simak T;Malomanova N;Fedorin I;Drobniewski F
通讯作者：
Drobniewski F
影响因子：
9.4
作者：
Kamerbeek, J;Schouls, L;vanEmbden, J
通讯作者：
vanEmbden, J