Dissimilar dosing with high-potency and low-potency neuroleptics.

Dissimilar dosing with high-potency and low-potency neuroleptics.
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高效和低效抗精神病药的剂量不同。

DOI:
10.1176/ajp.141.6.748
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发表时间:
1984
期刊:
The American journal of psychiatry
影响因子:
--
通讯作者:
Cotton,P
Cotton,P
中科院分区:
--
文献类型:
--
作者:
Baldessarini,RJ;Katz,B;Cotton,P

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作者研究了110名波士顿地区精神病住院患者的高效与低效精神抑制剂给药实践,并将研究结果与近16,000名退伍军人管理局患者的调查中报告的给药实践进行了比较。在两个样本中,最常见药物的平均氯丙嗪等效剂量密切相关。虽然两种药物的低剂量频率相似,但强效药物的剂量超过每日相当于1克氯丙嗪的剂量占处方的40%以上。常用强效药(氟哌啶醇或氟奋乃静)的平均氯丙嗪等效剂量是常用低效药(氯丙嗪或硫利达嗪)的3.54倍。强效药物通常用于躁狂症和精神分裂症,通常剂量相对较高,这可能会带来超过未经证实的额外益处的风险。
The authors studied high-potency versus low-potency neuroleptic dosing practices for 110 Boston-area psychiatric inpatients and compared the findings with the dosing practices reported in surveys of nearly 16,000 Veterans Administration patients. Mean chlorpromazine equivalent doses for the most common agents correlated strongly in both samples. Although frequencies of lower doses of both types of agents were similar, doses of potent drugs above the daily equivalent of 1 g of chlorpromazine accounted for more than 40% of prescriptions. The mean chlorpromazine-equivalent dose of popular potent agents (haloperidol or fluphenazine) was 3.54 times as high as that of popular low-potency agents (chlorpromazine or thioridazine). Potent agents are commonly used in mania and schizophrenia, often in relatively high doses, which may carry an excess of risk over unproven added benefit.
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期刊:
影响因子: --
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DOI: --
发表时间: 1983
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影响因子: 4.8
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