Mucosal immunoglobulins and B cells of teleost fish.
Mucosal immunoglobulins and B cells of teleost fish.
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DOI：
10.1016/j.dci.2011.11.009
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发表时间：
2011-12
影响因子：
2.9
通讯作者：
Sunyer, J. Oriol
中科院分区：
文献类型：
--
作者：
Salinas, Irene;Zhang, Yong-An;Sunyer, J. Oriol
作为将硬骨鱼类与外部环境隔离的物理屏障，粘膜也是保护它们免受微生物和应激源暴露的活性免疫部位。在哺乳动物中，抗原从粘膜表面取样的位点和初始T和B淋巴细胞刺激发生的位点被称为诱导位点，由粘膜相关淋巴组织（MALT）构成。硬骨鱼类的MALT按解剖位置可分为肠相关淋巴组织（GALT）、皮肤相关淋巴组织（SALT）和鳃相关淋巴组织（GIALT）。所有MALT都含有多种白细胞，包括但不限于T细胞、B细胞、浆细胞、巨噬细胞和粒细胞。分泌型免疫球蛋白主要由浆母细胞和浆细胞产生，并且在维持粘膜稳态中起关键作用。直到最近，硬骨鱼B细胞被认为只表达两种类型的免疫球蛋白，IgM和IgD，其中IgM被认为是唯一一种对全身和粘膜区室中的病原体都有反应的免疫球蛋白。然而，第三类硬骨鱼免疫球蛋白IgT/IgZ于2005年被发现，最近已显示其在肠道粘膜免疫应答中表现为普遍的免疫球蛋白。本文就鱼类MALT的黏膜免疫球蛋白和B细胞的研究进展作一综述。此外，我们试图整合现有的知识基础和应用研究成果的鱼粘膜免疫反应，其目标是提供新的方向，可能有助于开发新的疫苗接种策略，刺激不仅是全身，但也粘膜免疫。
As physical barriers that separate teleost fish from the external environment, mucosae are also active immunological sites that protect them against exposure to microbes and stressors. In mammals, the sites where antigens are sampled from mucosal surfaces and where stimulation of naive T and B lymphocytes occurs are known as inductive sites and are constituted by mucosa-associated lymphoid tissue (MALT). According to anatomical location, the MALT in teleost fish is subdivided into gut-associated lymphoid tissue (GALT), skin-associated lymphoid tissue (SALT), and gill-associated lymphoid tissue (GIALT). All MALT contain a variety of leukocytes, including, but not limited to, T cells, B cells, plasma cells, macrophages and granulocytes. Secretory immunoglobulins are produced mainly by plasmablasts and plasma cells, and play key roles in the maintenance of mucosal homeostasis. Until recently, teleost fish B cells were thought to express only two classes of immunoglobulins, IgM and IgD, in which IgM was thought to be the only one responding to pathogens both in systemic and mucosal compartments. However, a third teleost immunoglobulin class, IgT/IgZ, was discovered in 2005, and it has recently been shown to behave as the prevalent immunoglobulin in gut mucosal immune responses. The purpose of this review is to summarise the current knowledge of mucosal immunoglobulins and B cells of fish MALT. Moreover, we attempt to integrate the existing knowledge on both basic and applied research findings on fish mucosal immune responses, with the goal to provide new directions that may facilitate the development of novel vaccination strategies that stimulate not only systemic, but also mucosal immunity.
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影响因子：
4.7
作者：
Bermudez, R.;Vigliano, F.;Nieto, J. M.
通讯作者：
Nieto, J. M.
影响因子：
--
作者：
Austin B
通讯作者：
Austin B
影响因子：
2.6
作者：
Buchmann, K;Sigh, J;Dalgaard, M
通讯作者：
Dalgaard, M
影响因子：
5.5
作者：
Adelmann, Malte;Koellner, Bernd;Fichtner, Dieter
通讯作者：
Fichtner, Dieter
影响因子：
2
作者：
Åsbakk, K
通讯作者：
Åsbakk, K