Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults.
Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults.
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DOI：
10.1016/j.neuroimage.2022.118923
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发表时间：
2022-04-15
期刊：
影响因子：
5.7
通讯作者：
Fox, Peter T.
中科院分区：
文献类型：
--
作者：
Deng, Shengwen;Franklin, Crystal G.;O'Boyle, Michael;Zhang, Wei;Heyl, Betty L.;Jerabek, Paul A.;Lu, Hanzhang;Fox, Peter T.
源自血氧水平依赖性 (BOLD) fMRI 时程变化的基于体素的生理 (VBP) 变量包括：低频波动幅度 (ALFF)、低频波动分数幅度 (fALFF) 和区域均匀性 (ReHo)。尽管这些 BOLD 衍生变量可以检测组间（例如疾病与对照）空间模式差异，但生理学解释尚未明确。本研究的主要目的是量化 BOLD VBP 变量与脑代谢率和血流动力学 PET 测量值之间的空间对应关系，这是经过充分验证的生理标准。为此，在 16 名健康对照中获得了葡萄糖代谢率 (MRGlu; 18FDG) 和氧代谢率 (MRO2; 15OO)、血流量 (BF; H215O) 和血容量 (BV; C15O) 的定量全脑 PET 图像。在相同的受试者中，获得了用于计算 ALFF、fALFF 和 ReHo 图像的 BOLD 时间进程。 PET 变量与 BOLD 变量成对比较。在组平均跨区域分析中，ALFF 仅与 BV 显着对应（R = 0.64；p < 0.0001）。 fALFF 与 MRGlu 的相关性最强（R = 0.79；p < 0.0001），但与 MRO2 (R = 0.68)、BF (R = 0.68) 和 BV (R = 0.68) 的相关性也显着 (p < 0.0001)。 ReHo 的表现与 fALFF 类似，与 MRGlu (R = 0.78)、MRO2 (R = 0.54) 具有显着的强相关性 (p < 0.0001)，但与 BF (R = 0.50) 和 BV (R = 0.50) 的相关性较差。互信息分析进一步阐明了这些生理解释。当以 BV 为条件时，ALFF 没有保留显着的 MRGlu、MRO2 或 BF 信息。当以 MRGlu 为条件时，fALFF 和 ReHo 未保留显着的 MRO2、BF 或 BV 信息。然而，令人担忧的是，PET-BOLD 对应的强度因大脑区域的不同而存在显着差异，这需要未来对区域和每个受试者的生理解释进行研究。
Voxel-based physiological (VBP) variables derived from blood oxygen level dependent (BOLD) fMRI time-course variations include: amplitude of low frequency fluctuations (ALFF), fractional amplitude of low frequency fluctuations (fALFF) and regional homogeneity (ReHo). Although these BOLD-derived variables can detect between-group (e.g. disease vs control) spatial pattern differences, physiological interpretations are not well established. The primary objective of this study was to quantify spatial correspondences between BOLD VBP variables and PET measurements of cerebral metabolic rate and hemodynamics, being well-validated physiological standards. To this end, quantitative, whole-brain PET images of metabolic rate of glucose (MRGlu; 18FDG) and oxygen (MRO2; 15OO), blood flow (BF; H215O) and blood volume (BV; C15O) were obtained in 16 healthy controls. In the same subjects, BOLD time-courses were obtained for computation of ALFF, fALFF and ReHo images. PET variables were compared pair-wise with BOLD variables. In group-averaged, across-region analyses, ALFF corresponded significantly only with BV (R = 0.64; p < 0.0001). fALFF corresponded most strongly with MRGlu (R = 0.79; p < 0.0001), but also significantly (p < 0.0001) with MRO2 (R = 0.68), BF (R = 0.68) and BV (R = 0.68). ReHo performed similarly to fALFF, with significant strong correspondence (p < 0.0001) with MRGlu (R = 0.78), MRO2 (R = 0.54), and, but less strongly with BF (R = 0.50) and BV (R = 0.50). Mutual information analyses further clarified these physiological interpretations. When conditioned by BV, ALFF retained no significant MRGlu, MRO2 or BF information. When conditioned by MRGlu, fALFF and ReHo retained no significant MRO2, BF or BV information. Of concern, however, the strength of PET-BOLD correspondences varied markedly by brain region, which calls for future investigation on physiological interpretations at a regional and per-subject basis.
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影响因子：
5.7
作者：
Alexander-Bloch AF;Shou H;Liu S;Satterthwaite TD;Glahn DC;Shinohara RT;Vandekar SN;Raznahan A
通讯作者：
Raznahan A
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
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Smith, SM
影响因子：
4.3
作者：
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影响因子：
4
作者：
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通讯作者：
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影响因子：
2.8
作者：
Brickman, Adam M.;Small, Scott A.;Fleisher, Adam
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