Individualized adjustments to reference phantom internal organ dosimetry-scaling factors given knowledge of patient internal anatomy.
Individualized adjustments to reference phantom internal organ dosimetry-scaling factors given knowledge of patient internal anatomy.
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DOI：
10.1088/1361-6560/aab730
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发表时间：
2018-04-13
影响因子：
3.5
通讯作者：
Bolch WE
中科院分区：
文献类型：
--
作者：
Wayson MB;Bolch WE
目前有各种计算工具可用于诊断核医学中的患者器官剂量测定，但它们通常仅限于向ICRP定义的参考体模报告器官剂量。本研究，而其余的计算幻影为基础，提供了简单的工具来调整参考体模器官剂量的内部光子和电子源。各种各样的单能比吸收分数（SAF）的计算使用不同大小和间隔距离的组织球的辐射传输模拟。然后构建光子和电子自剂量和交叉剂量的缩放方法，通过患者特定体素体模模拟提供数据验证，并通过与MIRD第11号小册子中给出的缩放方法进行比较。光子和电子的自剂量被认为是依赖于辐射能量和球的大小。光子交叉剂量被认为是最独立的球体大小。电子交叉剂量被认为是依赖于球体的大小时，球体是在非常接近，由于电子范围的差异。验证研究表明，该数据集在预测高能量和低能量下的患者特异性光子剂量方面比MIRD 11方法更有效，但在100 keV和1 MeV之间的光子能量下给出了类似的结果。MIRD 11电子自剂量定标方法在较低能量时是准确的，但在较高能量时开始失效。本研究中开发的光子交叉剂量缩放方法显示，实际患者研究的准确度提高了9%，电子交叉剂量缩放方法显示，当仅缩放交叉剂量的韧致辐射分量时，准确度也提高了9%。这些剂量定标方法可随时纳入内部剂量测定软件，用于基于诊断体模的器官剂量测定。
Various computational tools are currently available that facilitate patient organ dosimetry in diagnostic nuclear medicine, yet they are typically restricted to reporting organ doses to ICRP-defined reference phantoms. The present study, while remaining computational phantom based, provides straightforward tools to adjust reference phantom organ dose for both internal photon and electron sources. A wide variety of monoenergetic specific absorbed fractions (SAFs) were computed using radiation transport simulations for tissue spheres of varying size and separation distance. Scaling methods were then constructed for both photon and electron self-dose and cross-dose, with data validation provided from patient-specific voxel phantom simulations, as well via comparison to the scaling methodology given in MIRD Pamphlet No. 11. Photon and electron self-dose was found to be dependent on both radiation energy and sphere size. Photon cross-dose was found to be mostly independent of sphere size. Electron cross-dose was found to be dependent on sphere size when the spheres were in close proximity, owing to differences in electron range. The validation studies showed that this dataset was more effective than the MIRD 11 method at predicting patient-specific photon doses for at both high and low energies, but gave similar results at photon energies between 100 keV and 1 MeV. The MIRD 11 method for electron self-dose scaling was accurate for lower energies but began to break down at higher energies. The photon cross-dose scaling methodology developed in this study showed gains in accuracy of up to 9% for actual patient studies, and the electron cross-dose scaling methodology showed gains in accuracy up to 9% as well when only the bremsstrahlung component of the cross-dose was scaled. These dose scaling methods are readily available for incorporation into internal dosimetry software for diagnostic phantom-based organ dosimetry.
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影响因子：
3.5
作者：
Zhang J;Na YH;Caracappa PF;Xu XG
通讯作者：
Xu XG
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3.5
作者：
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9.3
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影响因子：
9.3
作者：
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影响因子：
9.3
作者：
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通讯作者：
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