Phase Shifts to a Moderate Intensity Light Exposure in Older Adults: A Preliminary Report.
Phase Shifts to a Moderate Intensity Light Exposure in Older Adults: A Preliminary Report.
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DOI：
10.1177/0748730418818655
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发表时间：
2019-03
影响因子：
3.5
通讯作者：
Duffy, Jeanne F.
中科院分区：
文献类型：
--
作者：
Scheuermaier, Karine D.;Lee, Jung Hie;Duffy, Jeanne F.
与年龄相关的睡眠障碍与内源性昼夜节律的时间改变有关。有研究表明，老化的昼夜节律起搏器对光的敏感度降低。在这项研究中，我们旨在测试中等照度的光刺激是否会在老年人中产生显著的相移，以及这些相移是否会落在与我们之前在老年人中报告的照度响应曲线(IRC)一致的范围内。我们对12名健康的老年参与者(平均年龄58.3[4.2]岁，5名女性)进行了为期8天的住院研究。6.5h的多色白光曝光，目标照度为270勒克斯，从生物夜的早期开始进行。在光照前后，以血浆褪黑素数据作为昼夜节律相位标记物，进行昼夜节律相位估计。光刺激产生的平均相位延迟为1.78±0.77h，在~270lux的12个相位延迟中有10个落在模型的95%预测区间内，符合我们以前在老年人的IRC数据。这一发现表明，健康老年人的昼夜节律系统对中等强度光刺激的相位延迟效应很敏感。观察到的相移的大小与先前在老年人中描述的IRC一致。
Age-related disrupted sleep has been associated with modifications in the timing of endogenous circadian rhythms. There are studies suggesting a decreased sensitivity of the aging circadian pacemaker to light. In this study, we aimed to test whether a moderate illuminance light stimulus would produce significant phase shifts in older adults, and whether those would fall in a range consistent with the illuminance response curve (IRC) we previously reported in older adults. We conducted an 8-day in-patient study with 12 healthy older participants (mean age [SD], 58.3 [4.2] y, 5 females). A 6.5-h polychromatic white light exposure with a target illuminance of 270 lux was administered beginning in the early biological night. Before and after the light exposure, a circadian phase estimation procedure was carried out, with plasma melatonin data used as a circadian phase marker. The mean phase delay produced by the light stimulus was 1.78 ± 0.77 h. Ten of the 12 phase delay shifts at ~270 lux fell within the 95% predictive interval of the model fit to data from our previous IRC in older adults. This finding demonstrates that the circadian system of healthy older adults is sensitive to the phase-delaying effects of a moderate intensity light stimulus. The magnitude of the observed phase shifts is consistent with the previously described IRC in older adults.
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影响因子：
5.5
作者：
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DOI：
10.1111/j.1532-5415.2008.02164.x
发表时间：
2009-03-01
影响因子：
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作者：
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