Exploring the relationship of macrophage colony-stimulating factor levels on neuroaxonal metabolism and cognition during chronic human immunodeficiency virus infection.
Exploring the relationship of macrophage colony-stimulating factor levels on neuroaxonal metabolism and cognition during chronic human immunodeficiency virus infection.
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DOI：
10.3109/13550284.2010.513029
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发表时间：
2010-10
影响因子：
3.2
通讯作者：
Pomper MG
中科院分区：
文献类型：
--
作者：
Lentz MR;Degaonkar M;Mohamed MA;Kim H;Conant K;Halpern EF;Sacktor N;Barker PB;Pomper MG
巨噬细胞集落刺激因子（M-CSF）促进巨噬细胞分化，增加巨噬细胞对病毒感染的易感性，并增强受感染巨噬细胞中人类免疫缺陷病毒（HIV）的复制。鉴于目前的HIV神经发病机制模型涉及单核细胞进入中枢神经系统，与巨噬细胞成熟和存活相关的免疫因素可能与认知能力下降（通过神经心理学z评分[NPZ-8]或Memorial Sloan-Kettering [MSK]评分测量）和神经元完整性标志物N-乙酰天冬氨酸（NAA）的改变相关。54例慢性感染HIV+受试者在基线时接受了神经心理学评估、磁共振光谱成像和血浆和脑脊液（CSF）中M-CSF的定量。其中39例受试者在开始联合抗逆转录病毒治疗（ART）方案后3个月和10个月接受了进一步检查。在治疗使用的3个月内，CSF M-CSF和病毒RNA水平降低，而许多脑区的NAA浓度增加。无论是基线水平还是M-CSF水平的变化都不能预测联合ART使用10个月后观察到的NAA水平的变化。在研究入组时，CSF中M-CSF水平最低的受试者的认知障碍最轻（NPZ-8）。那些基线CSF MCSF水平较高且治疗后M-CSF下降幅度较大的患者，在10个月后往往会有更大的认知改善。在HIV感染的情况下，M-CSF的患病率增加可能导致神经元损伤，并可能预测认知功能障碍。
Macrophage colony-stimulating factor (M-CSF) promotes macrophage differentiation, increases susceptibility of macrophages to viral infection, and enhances human immunodeficiency virus (HIV) replication in infected macrophages. Given the current model of HIV neuropathogenesis, which involves monocyte trafficking into the central nervous system, immune factors linked with macrophage maturation and survival may be associated with cognitive decline (measured by neuropsychological z-score [NPZ-8] or Memorial Sloan-Kettering [MSK] score) and alterations in a marker of neuronal integrity, N-acetylaspartate (NAA). Fifty-four chronically infected HIV+ subjects underwent neuropsychological assessment, magnetic resonance spectroscopic imaging, and quantification of M-CSF in plasma and cerebrospinal fluid (CSF) at baseline. Thirty-nine of those subjects underwent further examination at 3 and 10 months after initiation of combination antiretroviral therapy (ART) regimens. Within 3 months of therapy use, CSF M-CSF and viral RNA levels were reduced, whereas NAA concentrations in many brain regions were increased. Neither baseline levels nor the change in M-CSF levels had the ability to predict changes in NAA levels observed after 10 months of combination ART use. At study entry those with the lowest M-CSF levels in the CSF had the least cognitive impairment (NPZ-8). Those who had higher baseline CSF MCSF levels and exhibited larger decreases in M-CSF after therapy, tended to have greater cognitive improvement after 10 months. Increased prevalence of M-CSF in the setting of HIV infection could contribute to neuronal injury and may be predictive of cognitive impairment.
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影响因子：
64.8
作者：
STANLEY, ER;CHEN, DM;LIN, HS
通讯作者：
LIN, HS
影响因子：
3.3
作者：
GALLO, P;PAGNI, S;TAVOLATO, B
通讯作者：
TAVOLATO, B
影响因子：
9.9
作者：
Stankoff, B;Tourbah, A;Lubetzki, C
通讯作者：
Lubetzki, C
DOI：
10.1006/jmrb.1993.1056
发表时间：
1993-08-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
KREIS, R;ERNST, T;ROSS, BD
通讯作者：
ROSS, BD
影响因子：
5.7
作者：
Chang, L;Ernst, T;Miller, E
通讯作者：
Miller, E