LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2.
LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2.
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LHX2通过上调SERPINE2的表达增强食管鳞状细胞癌的恶性表型
作者：
已经发现LHX 2失调存在于癌症中，但是LHX 2在食管鳞状细胞癌（ESCC）中的功能仍然未知。在这里，我们报告说，LHX 2在食管鳞癌组织中上调相比，LHX 2在邻近的正常组织中的水平。功能缺失和获得实验表明，LHX 2的敲低显著抑制ESCC细胞的增殖、迁移、侵袭、肿瘤生长和转移，而LHX 2的过表达具有相反的作用。LHX 2与SERPINE2基因启动子结合，调控SERPINE2基因的表达。总的来说，LHX 2促进ESCC肿瘤进展，它可能成为ESCC的潜在治疗靶点。
LHX2 dysregulations have been found to present in cancers, but the function of LHX2 in esophageal squamous cell carcinoma (ESCC) remains unknown. Here, we report that LHX2 was upregulated in ESCC tissues in comparison to the LHX2 levels in adjacent normal tissues. Loss- and gain-of-function experiments demonstrated that the knockdown of LHX2 markedly inhibited ESCC cells’ proliferation, migration, invasion, tumor growth and metastasis, whereas the overexpression of LHX2 had the opposite effects. A mechanistic investigation revealed that LHX2 bound to the promoter of SERPINE2 gene and transcriptionally regulated the expression of SERPINE2. Collectively, LHX2 facilitates ESCC tumor progression, and it could be a potential therapeutic target for ESCC.
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影响因子：
23.9
作者：
Folgueras AR;Guo X;Pasolli HA;Stokes N;Polak L;Zheng D;Fuchs E
通讯作者：
Fuchs E
影响因子：
5.8
作者：
Dokuni R;Nagano T;Jimbo N;Sato H;Kiriu T;Yasuda Y;Yamamoto M;Tachihara M;Kobayashi K;Maniwa Y;Nishimura Y
通讯作者：
Nishimura Y
影响因子：
3.1
作者：
Shen, Yuan;Wang, Xiaoyu;Lu, Lin
通讯作者：
Lu, Lin
影响因子：
44.1
作者：
Cui Y;Chen H;Xi R;Cui H;Zhao Y;Xu E;Yan T;Lu X;Huang F;Kong P;Li Y;Zhu X;Wang J;Zhu W;Wang J;Ma Y;Zhou Y;Guo S;Zhang L;Liu Y;Wang B;Xi Y;Sun R;Yu X;Zhai Y;Wang F;Yang J;Yang B;Cheng C;Liu J;Song B;Li H;Wang Y;Zhang Y;Cheng X;Zhan Q;Li Y;Liu Z
通讯作者：
Liu Z
影响因子：
29.4
作者：
Lin DC;Wang MR;Koeffler HP
通讯作者：
Koeffler HP