Pleiotropic Effect of Hormone Insulin-Like Growth Factor-I in Immune Response and Pathogenesis in Leishmaniases.
Pleiotropic Effect of Hormone Insulin-Like Growth Factor-I in Immune Response and Pathogenesis in Leishmaniases.
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DOI：
10.1155/2021/6614475
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发表时间：
2021
影响因子：
4.1
通讯作者：
Goto H
中科院分区：
文献类型：
--
作者：
Reis LC;Ramos-Sanchez EM;Araujo FN;Leal AF;Ozaki CY;Sevillano OR;Uscata BA;Goto H
利什曼病是由几种利什曼原虫引起的疾病，许多因素有助于感染的发展。由于适应性免疫反应不能完全解释利什曼原虫感染的结果，并考虑到初始事件在感染的建立中至关重要，我们研究了一种生长因子，胰岛素样生长因子-I（IGF-I），发现于循环中，由不同的细胞（包括巨噬细胞）产生，并存在于寄生虫接种的皮肤中。在此，我们回顾IGF-I在利什曼病实验模型和人类患者中的作用。IGF-I在体外诱导不同种类利什曼原虫的生长，并改变疾病结果，增加寄生虫负荷和病变大小，特别是在利什曼原虫中。major和L.亚马逊河病毒感染的小鼠利什曼病。IGF-I影响与存在于利什曼原虫上的IGF-I受体相互作用的寄生虫。在利什曼原虫-巨噬细胞相互作用期间，IGF-I作用于精氨酸代谢途径，导致巨噬细胞和利什曼原虫中的多胺产生。IGF-I和细胞因子相互作用，相互影响其表达。IL-4是L.主要在鼠利什曼病中，但我们观察到IGF-I作为IL-4的效应元件令人惊讶地起作用。接近人类利什曼病，粘膜，播散性和内脏疾病的患者呈现出令人惊讶的低IGF-I血清水平，这表明不同的影响比寄生虫生长。我们观察到低IGF-I水平可能有助于人类皮肤利什曼病的炎症反应持续和延迟损伤愈合以及内脏利什曼病的贫血发展。我们必须强调感染的复杂性，这取决于利什曼原虫的种类和寄生虫的发育阶段。由于IGF-I在相互作用和疾病发病机制的生物学上发挥多效性作用，IGF-I成为探索感染发展背后的生物学和致病过程的有吸引力的工具。IGF-I的多效性作用进一步打开了接近IGF-I作为治疗靶点的可能性。
Leishmaniases are diseases caused by several Leishmania species, and many factors contribute to the development of the infection. Because the adaptive immune response does not fully explain the outcome of Leishmania infection and considering that the initial events are crucial in the establishment of the infection, we investigated one of the growth factors, the insulin-like growth factor-I (IGF-I), found in circulation and produced by different cells including macrophages and present in the skin where the parasite is inoculated. Here, we review the role of IGF-I in leishmaniasis experimental models and human patients. IGF-I induces the growth of different Leishmania species in vitro and alters the disease outcome increasing the parasite load and lesion size, especially in L. major- and L. amazonensis-infected mouse leishmaniasis. IGF-I affects the parasite interacting with the IGF-I receptor present on Leishmania. During Leishmania-macrophage interaction, IGF-I acts on the arginine metabolic pathway, resulting in polyamine production both in macrophages and Leishmania. IGF-I and cytokines interact with reciprocal influences on their expression. IL-4 is a hallmark of susceptibility to L. major in murine leishmaniasis, but we observed that IGF-I operates astoundingly as an effector element of the IL-4. Approaching human leishmaniasis, patients with mucosal, disseminated, and visceral diseases presented surprisingly low IGF-I serum levels, suggesting diverse effects than parasite growth. We observed that low IGF-I levels might contribute to the inflammatory response persistence and delayed lesion healing in human cutaneous leishmaniasis and the anemia development in visceral leishmaniasis. We must highlight the complexity of infection revealed depending on the Leishmania species and the parasite's developmental stages. Because IGF-I exerts pleiotropic effects on the biology of interaction and disease pathogenesis, IGF-I turns up as an attractive tool to explore biological and pathogenic processes underlying infection development. IGF-I pleiotropic effects open further the possibility of approaching IGF-I as a therapeutical target.
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DOI：
10.1111/j.1550-7408.1990.tb01157.x
发表时间：
1990-09-01
期刊：
JOURNAL OF PROTOZOOLOGY
影响因子：
--
作者：
CHARLAB, R;BLAINEAU, C;BARCINSKI, MA
通讯作者：
BARCINSKI, MA
影响因子：
4.3
作者：
Aydin F;Kaya A;Karapinar L;Kumbaraci M;Imerci A;Karapinar H;Karakuzu C;Incesu M
通讯作者：
Incesu M
影响因子：
5.7
作者：
Barrios, Monica R.;Campos, Viviane C.;Jesus, Amelia M. R.
通讯作者：
Jesus, Amelia M. R.
影响因子：
3.7
作者：
Barrett, James P.;Minogue, Aedin M.;Lynch, Marina A.
通讯作者：
Lynch, Marina A.
影响因子：
3.1
作者：
Cardoso, Thiago Marconi;Machado, Alvaro;Bacellar, Olivia
通讯作者：
Bacellar, Olivia