IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers.
IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers.
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DOI：
10.1155/2013/567834
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发表时间：
2013
影响因子：
4.3
通讯作者：
Incesu M
中科院分区：
文献类型：
--
作者：
Aydin F;Kaya A;Karapinar L;Kumbaraci M;Imerci A;Karapinar H;Karakuzu C;Incesu M
目标.研究胰岛素样生长因子I（IGF-1）水平对糖尿病足溃疡高压氧治疗（HBOT）的反应，并确定IGF-1是否是糖尿病足溃疡患者伤口愈合的预测指标。设计和方法。我们用HBOT治疗了48例糖尿病足溃疡患者。比较HBOT治疗后伤口愈合患者与未从HBOT中获益患者IGF-1水平的变化。结果两组间初始IGF-1水平无显著差异（P = 0.399）。IGF-1水平随高压氧治疗时间延长而升高（P < 0.05）。愈合组IGF-1的平均增量和最终值均显著高于对照组（P < 0.05）。未愈合组IGF-1平均增加值为负值，最终值差异无统计学意义（P < 0.05）。治疗组IGF-1水平升高明显高于对照组（P < 0.001）。结论. IGF-1在愈合组明显升高。我们认为，HBOT是有效的治疗糖尿病足溃疡，与IGF-1的升高。这种改变似乎是用HBOT治疗的糖尿病足溃疡的伤口愈合的预测因素。
Objectives. To investigate insulin-like growth factor I (IGF-1) levels in response to hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers and to determine whether IGF-1 is a predictive indicator of wound healing in patients with diabetic foot ulcers. Design and Methods. We treated 48 consecutive patients with diabetic foot ulcers with HBOT. Alterations of IGF-1 levels in patients whose wound healed with HBOT were compared with those in patients who did not benefit from HBOT. Results. There was no significant difference in initial IGF-1 levels between the two groups (P = 0.399). The mean IGF-1 level increased with HBOT (P < 0.05). In the healed group, the mean IGF-1 increase and the final values were significantly higher (P < 0.05). In the nonhealed group, the mean IGF-1 increase was minus and the final values were not significantly different (P < 0.05). The increase in IGF-1 level with HBOT was significantly higher in the healed group (P < 0.001). Conclusions. IGF-1 increased significantly in the healed group. We believe that HBOT is effective in the treatment of diabetic foot ulcers, with an elevation of IGF-1. This alteration seems to be a predictive factor for wound healing in diabetic foot ulcers treated with HBOT.
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影响因子：
2.6
作者：
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通讯作者：
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影响因子：
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DOI：
10.1007/s11626-011-9418-3
发表时间：
2011-08-01
影响因子：
2.1
作者：
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通讯作者：
Ortiz-Monasterio, Fernando