Evaluating 3D-printed bioseparation structures using multi-length scale tomography.
Evaluating 3D-printed bioseparation structures using multi-length scale tomography.
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DOI：
10.1007/s00216-023-04866-6
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发表时间：
2023-10
影响因子：
4.3
通讯作者：
Bracewell, Daniel G.
中科院分区：
文献类型：
--
作者：
Johnson, Thomas F.;Conti, Mariachiara;Iacoviello, Francesco;Shearing, Paul R.;Pullen, James;Dimartino, Simone;Bracewell, Daniel G.
将X射线计算机断层扫描应用于用于生物分离的3D打印gyroids成像，以可视化和表征从整个几何形状到单个纳米孔的结构。甲基丙烯酸酯印刷品的特征尺寸为500 µm、300 µm和200 µm，材料相在所有情况下均表现出多孔子结构。两台X射线扫描仪实现了从5 µm到16 nm的像素尺寸，以产生多个长度尺度的样品数字表示，作为几何分析和流动模拟的基础。在螺旋体尺度下，将成像样品与原始计算机辅助设计进行视觉比较，以分析所有特征尺寸的印刷保真度。将单个500 µm特征（整体螺旋结构的一部分）在设计和成像体积之间进行比较和叠加，以识别单个打印层。所有特征尺寸的内部子体积被分割成材料和空隙相，用于渗透流分析。小块的3D打印材料被优化用于63 nm像素大小的纳米断层成像，所有三个陀螺样品在测量时都表现出相似的几何特征。获得的平均孔隙率为45%，在预期的设计范围内，测得的弯曲因子为2.52。应用空隙率网络图能够识别孔的尺寸、位置和连通性，获得793 nm的平均孔径。在7.00 × 10−11 m2s−1的体积扩散率下使用Avizo XLAB，得到的模拟材料扩散率为2.17 × 10−11 m2s−1 ± 0.16 × 10−11 m2s−1。
X-ray computed tomography was applied in imaging 3D-printed gyroids used for bioseparation in order to visualize and characterize structures from the entire geometry down to individual nanopores. Methacrylate prints were fabricated with feature sizes of 500 µm, 300 µm, and 200 µm, with the material phase exhibiting a porous substructure in all cases. Two X-ray scanners achieved pixel sizes from 5 µm to 16 nm to produce digital representations of samples across multiple length scales as the basis for geometric analysis and flow simulation. At the gyroid scale, imaged samples were visually compared to the original computed-aided designs to analyze printing fidelity across all feature sizes. An individual 500 µm feature, part of the overall gyroid structure, was compared and overlaid between design and imaged volumes, identifying individual printed layers. Internal subvolumes of all feature sizes were segmented into material and void phases for permeable flow analysis. Small pieces of 3D-printed material were optimized for nanotomographic imaging at a pixel size of 63 nm, with all three gyroid samples exhibiting similar geometric characteristics when measured. An average porosity of 45% was obtained that was within the expected design range, and a tortuosity factor of 2.52 was measured. Applying a voidage network map enabled the size, location, and connectivity of pores to be identified, obtaining an average pore size of 793 nm. Using Avizo XLAB at a bulk diffusivity of 7.00 × 10−11 m2s−1 resulted in a simulated material diffusivity of 2.17 × 10−11 m2s−1 ± 0.16 × 10−11 m2s−1.
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影响因子：
4.6
作者：
Burnett TL;McDonald SA;Gholinia A;Geurts R;Janus M;Slater T;Haigh SJ;Ornek C;Almuaili F;Engelberg DL;Thompson GE;Withers PJ
通讯作者：
Withers PJ
影响因子：
2
作者：
Bailey JJ;Heenan TMM;Finegan DP;Lu X;Daemi SR;Iacoviello F;Backeberg NR;Taiwo OO;Brett DJL;Atkinson A;Shearing PR
通讯作者：
Shearing PR
影响因子：
9.5
作者：
Femmer, Tim;Kuehne, Alexander J. C.;Wessling, Matthias
通讯作者：
Wessling, Matthias
DOI：
10.1002/advs.201700369
发表时间：
2018-01
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Finegan DP;Darcy E;Keyser M;Tjaden B;Heenan TMM;Jervis R;Bailey JJ;Vo NT;Magdysyuk OV;Drakopoulos M;Michiel MD;Rack A;Hinds G;Brett DJL;Shearing PR
通讯作者：
Shearing PR
影响因子：
4.3
作者：
Idkowiak, Jakub;Jirasko, Robert;Holcapek, Michal
通讯作者：
Holcapek, Michal