The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis.
The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis.
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DOI：
10.1083/jcb.129.5.1177
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发表时间：
1995-06
影响因子：
7.8
通讯作者：
MICHALOPOULOS, GK
中科院分区：
文献类型：
--
作者：
ZARNEGAR, R;MICHALOPOULOS, GK
特别是在过去几年进行的研究已经清楚地表明，除了肝脏，肝细胞生长因子（HGF） 1几乎影响身体的每一个组织，从神经系统到免疫和网状内皮系统。最近的研究结果还表明，靶细胞对HGF的生物学反应并不局限于诱导细胞增殖和运动本身，而是包括多种作用，如抑制细胞生长、诱导形态发生、刺激T细胞粘附内皮和迁移、增强神经元存活和调节红细胞分化。此外，HGF受体如Met、HGF相关因子如HGF样蛋白、HGF样受体如Ron（一种类似于HGF受体的跨膜酪氨酸激酶）的发现，为HGF的性质及其不断增长的家族增加了更多的复杂性。
ESEARCH performed over the past few years, in particular, has made it clear that, in addition to the liver, hepatocyte growth factor (HGF) 1 affects virtually every tissue in the body ranging from the nervous system to the immune and reticuloendothelial systems. Recent findings have also revealed that the biological responses of target cells to HGF are not confined to the induction of cell proliferation and motility per se but include a plethora of effects such as inhibition of cell growth, induction of morphogenesis, stimulation of T cell adhesion to endothelium and migration, enhancement of neuron survival, and regulation of erythroid differentiation. Furthermore, the discoveries of the HGF receptor as Met, of an HGF-related factor, called HGF-like protein, and of HGF-like's receptor as Ron, a transmembrane tyrosine kinase similar to the HGF receptor, have added yet more levels of complexity to the nature of HGF and its now growing family.
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影响因子：
64.8
作者：
NAKAMURA, T;NISHIZAWA, T;SHIMIZU, S
通讯作者：
SHIMIZU, S
影响因子：
20.3
作者：
IWAMA, A;OKANO, K;SUDA, T
通讯作者：
SUDA, T
DOI：
10.1006/bbrc.1993.1801
发表时间：
1993-07-15
影响因子：
3.1
作者：
MIZUNO, K;HIGUCHI, O;NAKAMURA, T
通讯作者：
NAKAMURA, T
DOI：
10.1073/pnas.91.12.5281
发表时间：
1994-06-07
影响因子：
11.1
作者：
NAIDU, YM;ROSEN, EM;NICKOLOFF, BJ
通讯作者：
NICKOLOFF, BJ
影响因子：
7.7
作者：
OTONKOSKI, T;BEATTIE, GM;HAYEK, A
通讯作者：
HAYEK, A