Reduced nucleus accumbens and caudate nucleus activation to a pleasant taste is associated with obesity in older adults.
Reduced nucleus accumbens and caudate nucleus activation to a pleasant taste is associated with obesity in older adults.
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DOI：
10.1016/j.brainres.2011.02.071
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发表时间：
2011-04-22
期刊：
影响因子：
2.9
通讯作者：
Murphy C
中科院分区：
文献类型：
--
作者：
Green E;Jacobson A;Haase L;Murphy C
虽然肥胖症被认为是一种全球健康流行病，但对于人口中增长最快的部分--老年人--肥胖症患病率的上升，研究还不够深入。晚年肥胖与身体健康和认知功能的下降有关，不仅对个人，而且对社会都有影响。我们研究了大脑对食物奖励的反应改变与肥胖有关的假设，使用fMRI对执行享乐评估任务的年轻人和老年人对愉快和厌恶的味觉刺激的反应进行了研究。在老年人中，腹部脂肪/体重指数较高的水平与多巴胺相关脑区(尾状核、伏隔核)对蔗糖的fMRI激活减少之间的相关性很大。功能低下的奖赏反应和肥胖之间的显著关联表明，多巴胺功能下降可能是老年人体重增加的一个合理机制。
Although obesity is recognized as a global health epidemic, insufficient research has been directed to understanding the rising prevalence of obesity in the fastest growing segment of the population, older adults. Late-life obesity has been linked to declines in physical health and cognitive function, with implications not only for the individual, but also for society. We investigated the hypothesis that altered brain responses to food reward is associated with obesity, using fMRI of response to pleasant and aversive taste stimuli in young and older adults performing a hedonic evaluation task. Correlations between higher levels of abdominal fat/body mass index and reduced fMRI activation to sucrose in dopamine-related brain regions (caudate, nucleus accumbens) were large in older adults. Significant associations between a hypofunctioning reward response and obesity suggest the hypothesis that decreased dopamine functioning may be a plausible mechanism for weight gain in older adults.
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影响因子：
5.7
作者：
Haase L;Cerf-Ducastel B;Murphy C
通讯作者：
Murphy C
DOI：
10.1177/194589240602000119
发表时间：
2006-01-01
期刊：
AMERICAN JOURNAL OF RHINOLOGY
影响因子：
--
作者：
Harris, R;Davidson, TM;Chen, M
通讯作者：
Chen, M
DOI：
10.1073/pnas.0802127105
发表时间：
2008-09-30
影响因子：
11.1
作者：
Dreher, Jean-Claude;Meyer-Lindenberg, Andreas;Berman, Karen Faith
通讯作者：
Berman, Karen Faith
影响因子：
3.5
作者：
GREEN, BG;SHAFFER, GS;GILMORE, MM
通讯作者：
GILMORE, MM
影响因子：
2.9
作者：
Bartoshuk, LM;Duffy, V;Weiffenbach, JM
通讯作者：
Weiffenbach, JM