Cortical activation in response to pure taste stimuli during the physiological states of hunger and satiety.
Cortical activation in response to pure taste stimuli during the physiological states of hunger and satiety.
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DOI：
10.1016/j.neuroimage.2008.09.044
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发表时间：
2009-02-01
期刊：
影响因子：
5.7
通讯作者：
Murphy C
中科院分区：
文献类型：
--
作者：
Haase L;Cerf-Ducastel B;Murphy C
这项事件相关功能磁共振成像（er-fMRI）研究探讨了BOLD信号的变化，响应于一系列的纯味觉刺激，不同的刺激质量时，受试者饥饿和饱与营养预负荷。组分析显示，在饥饿减饱足状态下，丘脑、海马和海马旁对蔗糖、咖啡因、糖精和柠檬酸的反应存在显著差异。当检查的饥饿和饱足的条件下，激活不同的功能的刺激，与大多数的刺激表现出显着更大的激活在饥饿状态下的丘脑，黑质，在相反的减少激活在饱足状态下的海马体，海马，杏仁核，前扣带回。感兴趣区域（ROI）分析揭示了两个显着的相互作用，ROI的生理和生理刺激的ROI。在饱腹感条件下，初级（下位和上级岛）和次级（OFC 11和OFC 47）味觉区域对所有刺激的反应比参与加工进食行为（下丘脑）、情感（杏仁核）和记忆（海马、海马旁和内嗅皮层）的区域表现出显著更大的大脑激活。除了上级脑区外，这些区域在饥饿状态下的激活程度明显高于饱腹状态。此外，激活的模式不同的功能味觉刺激，更大的激活响应蔗糖比其他刺激。这些不同的激活模式表明，饥饿和饱足的生理状态在多个大脑区域产生不同的激活，以响应不同的纯味觉刺激。
This event-related functional magnetic resonance imaging (er-fMRI) study investigated BOLD signal change in response to a series of pure gustatory stimuli that varied in stimulus quality when subjects were hungry and sated with a nutritional preload. Group analyses showed significant differences in activation in the hunger minus satiety condition in response to sucrose, caffeine, saccharin, and citric acid within the thalamus, hippocampus, and parahippocampus. When examining the hunger and satiety conditions, activation varied as a function of stimulus, with the majority of the stimuli exhibiting significantly greater activation in the hunger state within the insula, thalamus, and substantia nigra, in contrast to decreased activation in the satiated state within the parahippocampus, hippocampus, amygdala, and anterior cingulate. Region of interest (ROI) analysis revealed two significant interactions, ROI by physiology and ROI by physiology by stimulus. In the satiety condition, the primary (inferior and superior insulae) and secondary (OFC 11 and OFC 47) taste regions exhibited significantly greater brain activation in response to all stimuli than regions involved in processing eating behavior (hypothalamus), affect (amygdala), and memory (hippocampus, parahippocampus and entorhinal cortex). These same regions demonstrated significantly greater activation within the hunger condition than the satiety condition, with the exception of the superior insula. Furthermore, the patterns of activation differed as a function taste stimulus, with greater activation in response to sucrose than to the other stimuli. These differential patterns of activation suggest that the physiological states of hunger and satiety produce divergent activation in multiple brain areas in response to different pure gustatory stimuli.
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影响因子：
3.5
作者：
Cerf-Ducastel, B;Ven de Moortele, PF;Faurion, A
通讯作者：
Faurion, A
DOI：
10.1111/j.1749-6632.1998.tb10623.x
发表时间：
1998-01-01
期刊：
OLFACTION AND TASTE XII
影响因子：
--
作者：
Faurion, A;Cerf, B;Pillias, AM
通讯作者：
Pillias, AM
影响因子：
2.9
作者：
Bartoshuk, LM;Duffy, V;Weiffenbach, JM
通讯作者：
Weiffenbach, JM
影响因子：
56.9
作者：
BARTOSHUK, LM;PFAFFMANN, C;MCBURNEY, DH
通讯作者：
MCBURNEY, DH
DOI：
10.1073/pnas.96.5.2532
发表时间：
1999-03-02
影响因子：
11.1
作者：
Denton, D;Shade, R;Fox, P
通讯作者：
Fox, P