High Tumor Mitochondrial DNA Content Correlates With an Improved Patient's Outcome in WHO Grade III Meningioma.
High Tumor Mitochondrial DNA Content Correlates With an Improved Patient's Outcome in WHO Grade III Meningioma.
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高肿瘤线粒体 DNA 含量与 WHO III 级脑膜瘤患者预后的改善相关
DOI：
10.3389/fonc.2020.542294
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发表时间：
2020
影响因子：
4.7
通讯作者：
Gong Y
中科院分区：
文献类型：
--
作者：
Hua L;Juratli TA;Zhu H;Deng J;Wang D;Sun S;Xie Q;Wakimoto H;Gong Y
背景：研究表明，线粒体基因组含量（mtDNA含量）在许多恶性肿瘤中存在差异。然而，其在高级别脑膜瘤中的分布和预后价值仍然很大程度上未知。在这项回顾性研究中，我们试图评估mtDNA含量和临床特征之间的假定相关性。方法：采用qPCR方法提取87例世界卫生组织III级脑膜瘤患者的线粒体DNA。mtDNA含量在WHO III级脑膜瘤中的分布及其与临床变量的相关性进行了评估。此外，我们的预后价值也被确定。结果：平均mtDNA含量为617.7（范围，0.8-3000）。不同组织学类型间mtDNA分布差异无统计学意义（P = 0.07）。术前放疗的肿瘤与较低的mtDNA含量相关（P = 0.041），而与其他临床变量无相关性。高mtDNA含量与PFS（P = 0.044）和OS（P = 0.019）显著更好相关。然而，在接受术后放疗的患者中，低mtDNA含量与较好的PFS相关（P = 0.028），而OS无差异（P = 0.272）。在ER阴性患者亚组中，mtDNA含量低也与OS和PFS较好相关（PFS，P = 0.002; OS，P = 0.002）。结论：与其他肿瘤一致，在我们的队列中，高mtDNA含量与WHO III级脑膜瘤的预后较好相关。然而，对于接受术后放射治疗的患者，低mtDNA含量与更好的PFS相关。这些研究结果表明，mtDNA含量可以进一步探索作为高级别脑膜瘤患者和接受术后放射治疗的患者的潜在生物标志物。
Background: Studies have shown mitochondrial genome content (mtDNA content) varies in many malignancies. However, its distribution and prognostic values in high-grade meningioma remain largely unknown. In this retrospective study, we sought to assess a putative correlation between the mtDNA content and clinical characteristics. Methods: Mitochondrial DNA was extracted from 87 World Health Organization grade III meningioma samples using a qPCR method. The distribution of mtDNA content in WHO grade III meningioma and its correlations with clinical variables were assessed. Furthermore, we prognostic values were also determined. Results: Mean mtDNA content was 617.7 (range, 0.8–3000). There was no mtDNA distribution difference based on the histological subtypes (P = 0.07). Tumors with preoperative radiation were associated with lower mtDNA content (P = 0.041), whereas no correlations with other clinical variables were observed. A high mtDNA content was associated with significantly better PFS (P = 0.044) and OS (P = 0.019). However, in patients who received postoperative radiotherapy, low mtDNA content was associated with better PFS (P = 0.028), while no difference in OS was observed (P = 0.272). Low mtDNA content was also associated with better OS and PFS in subgroups of patients with ER negative status (PFS, P = 0.002; OS, P = 0.002). Conclusions: Consistent with other tumors, high mtDNA content was associated with better outcome in WHO grade III meningioma in our cohort. However, for patients who received post-operative radiation therapy, low mtDNA content was associated with better PFS. These findings suggest that mtDNA content may further be explored as a potential biomarker for high-grade meningioma patients and for those who received postoperative radiation therapy.
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影响因子：
6.4
作者：
Goutagny, Stephane;Nault, Jean C.;Kalamarides, Michel
通讯作者：
Kalamarides, Michel
影响因子：
11.5
作者：
Jiang, WW;Rosenbaum, E;Califano, JA
通讯作者：
Califano, JA
影响因子：
--
作者：
Bai RK;Chang J;Yeh KT;Lou MA;Lu JF;Tan DJ;Liu H;Wong LJ
通讯作者：
Wong LJ
影响因子：
9.7
作者：
Liang, BC;Hays, L
通讯作者：
Hays, L
影响因子：
4.8
作者：
Juratli, Tareq A.;Brastianos, Priscilla K.;Cahill, Daniel P.
通讯作者：
Cahill, Daniel P.