Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals.

Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals.
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DOI:
10.1146/annurev-virology-091919-101238
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发表时间:
2021-09-29
影响因子:
11.3
通讯作者:
Duerkop BA
Duerkop BA
中科院分区:
医学2区
文献类型:
--
作者:
Kirsch JM;Brzozowski RS;Faith D;Round JL;Secor PR;Duerkop BA

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细菌和它们的病毒(噬菌体或噬菌体)在多微生物群落(如动物肠道)中相互拮抗和有益。这些相互作用是多方面的,并受到环境条件的影响。在这篇综述中,我们讨论了噬菌体-细菌的相互作用,因为它们涉及到肠道的复杂环境。在哺乳动物和无脊椎动物的肠道内,细菌和细菌参与各种相互作用,包括通过溶原性的遗传共存,并且细菌直接调节微生物群组成和免疫系统,其后果被认为是健康和疾病的潜在驱动因素。随着对肠道中噬菌体-细菌相互作用及其结果的深入了解,未来的噬菌体疗法成为可能。
Bacteria and their viruses (bacteriophages or phages) interact antagonistically and beneficially in polymicrobial communities such as the guts of animals. These interactions are multifaceted and are influenced by environmental conditions. In this review, we discuss phage-bacteria interactions as they relate to the complex environment of the gut. Within the mammalian and invertebrate guts, phages and bacteria engage in diverse interactions including genetic coexistence through lysogeny, and phages directly modulate microbiota composition and the immune system with consequences that are becoming recognized as potential drivers of health and disease. With greater depth of understanding of phage-bacteria interactions in the gut and the outcomes, future phage therapies become possible.
DOI: 10.1371/journal.pgen.1009204
发表时间: 2021-01
期刊: PLoS genetics
影响因子: 4.5
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