The phenomics and genetics of addictive and affective comorbidity in opioid use disorder.
The phenomics and genetics of addictive and affective comorbidity in opioid use disorder.
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DOI：
10.1016/j.drugalcdep.2021.108602
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发表时间：
2021-04-01
影响因子：
4.2
通讯作者：
Kranzler HR
中科院分区：
文献类型：
--
作者：
Freda PJ;Moore JH;Kranzler HR
阿片类药物使用障碍(OUD)在世界范围内造成重大的公共卫生和经济负担。因此，了解导致OUD发展的风险因素对于降低其患病率和影响至关重要。OUD风险的重要来源包括共同发生的一生和当前诊断的精神障碍，主要是情绪障碍和其他物质使用障碍，以及独特和共有的遗传因素。尽管OUD与情绪和物质使用障碍之间似乎存在多效性，但对OUD风险的这方面了解甚少。在这篇综述中，我们描述了成瘾和情感性合并症作为OUD发展的危险因素的患病率和临床意义，作为合理开具阿片类药物处方和OUD治疗的基础，并加强努力预防该疾病。我们还回顾了与OUD和其他成瘾和情感障碍相关的遗传变异，以突出未来研究和风险评估方案的目标。
Opioid use disorder (OUD) creates significant public health and economic burdens worldwide. Therefore, understanding the risk factors that lead to the development of OUD is fundamental to reducing both its prevalence and its impact. Significant sources of OUD risk include co-occurring lifetime and current diagnoses of both psychiatric disorders, primarily mood disorders, and other substance use disorders, and unique and shared genetic factors. Although there appears to be pleiotropy between OUD and both mood and substance use disorders, this aspect of OUD risk is poorly understood. In this review, we describe the prevalence and clinical significance of addictive and affective comorbidities as risk factors for OUD development as a basis for rational opioid prescribing and OUD treatment and to improve efforts to prevent the disorder. We also review the genetic variants that have been associated with OUD and other addictive and affective disorders to highlight targets for future study and risk assessment protocols.
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