Mephedrone (4-methylmethcathinone) and intracranial self-stimulation in C57BL/6J mice: comparison to cocaine.
Mephedrone (4-methylmethcathinone) and intracranial self-stimulation in C57BL/6J mice: comparison to cocaine.
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DOI：
10.1016/j.bbr.2012.06.012
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发表时间：
2012-09-01
影响因子：
2.7
通讯作者：
Malanga, C. J.
中科院分区：
文献类型：
--
作者：
Robinson, J. Elliott;Agoglia, Abigail E.;Fish, Eric W.;Krouse, Michael C.;Malanga, C. J.
在过去五年中，娱乐性使用卡西酮衍生的合成兴奋剂（也称为“浴盐”）的情况有所增加。这类药物中一种常见的滥用药物是甲氧麻黄酮（4-甲基甲卡西酮或“喵喵”），它会改变人类的情绪并产生欣快感。颅内自我刺激（ICSS）测量神经活性化合物对大脑奖赏回路的行为影响。我们使用ICSS来研究甲氧麻黄酮和可卡因改变C57 BL/6 J小鼠内侧前脑束电刺激反应的能力。成年雄性C57 BL/6 J小鼠（n=6）植入单极刺激电极的水平下丘脑外侧的反应不同频率的脑刺激奖励（BSR）。在腹腔注射生理盐水、甲氧麻黄酮（1.0、3.0、10.0mg/kg）或可卡因（1.0、3.0、10.0mg/kg）前后，测定支持半数最大反应的频率（EF_（50））、BSR阈值（θ0）和最大反应率。吗啡酮剂量依赖性地降低EF 50（最大值）。效应=基线的72.3%）、θ0（最大值）效果=基线的59.6%）和最大响应率（最大。效应=基线的67.0%）。给药后立即开始，可卡因剂量依赖性地降低EF 50（最大值）。效应=基线的66.4%）和θ0（最大效应=基线的60.1%），但不影响最大应答率。这些结果表明，甲氧麻黄酮，像可卡因，加强BSR，这可能表明其滥用的潜力。鉴于兴奋剂滥用的公共卫生问题，未来的研究将是必要的，以确定急性和慢性甲氧麻黄酮使用的细胞和行为的影响。
The recreational use of cathinone-derived synthetic stimulants, also known as “bath salts”, has increased during the last five years. A commonly abused drug in this class is mephedrone (4-methylmethcathinone or “meow–meow”), which alters mood and produces euphoria in humans. Intracranial self-stimulation (ICSS) measures the behavioral effects of neuroactive compounds on brain reward circuitry. We used ICSS to investigate the ability of mephedrone and cocaine to alter responding for electrical stimulation of the medial forebrain bundle in C57BL/6J mice. Adult male C57BL/6J mice (n=6) implanted with unipolar stimulating electrodes at the level of the lateral hypothalamus responded for varying frequencies of brain stimulation reward (BSR). The frequency that supported half maximal responding (EF50), the BSR threshold (θ0), and the maximum response rate were determined before and after intraperitoneal administration of saline, mephedrone (1.0, 3.0, or 10.0mg/kg), or cocaine (1.0, 3.0, or 10.0mg/kg). Mephedrone dose-dependently decreased EF50 (max. effect=72.3% of baseline), θ0(max. effect=59.6% of baseline), and the maximum response rate (max. effect=67.0% of baseline) beginning 15min after administration. Beginning immediately after administration, cocaine dose-dependently lowered EF50 (max. effect=66.4% of baseline) and θ0(max. effect=60.1% of baseline) but did not affect maximum response rate. These results suggest that mephedrone, like cocaine, potentiates BSR, which may indicate its potential for abuse. Given the public health concern of stimulant abuse, future studies will be necessary to determine the cellular and behavioral effects of acute and chronic mephedrone use.
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影响因子：
3.4
作者：
Elmer, Greg I.;Pieper, Jeanne O.;Hamilton, Lindsey R.;Wise, Roy A.
通讯作者：
Wise, Roy A.
影响因子：
5
作者：
OLDS, ME;YUWILER, A
通讯作者：
YUWILER, A
影响因子：
56.9
作者：
RITZ, MC;LAMB, RJ;KUHAR, MJ
通讯作者：
KUHAR, MJ
影响因子：
14.8
作者：
Carlezon, William A., Jr.;Chartoff, Elena H.
通讯作者：
Chartoff, Elena H.
DOI：
10.1111/j.1530-0277.2009.01069.x
发表时间：
2010-01-01
影响因子：
3.2
作者：
Fish, Eric W.;Riday, Thorfinn T.;Malanga, C. J.
通讯作者：
Malanga, C. J.