N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.
N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.
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DOI：
10.1002/ana.23689
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发表时间：
2012-12
影响因子：
11.2
通讯作者：
Wandinger, Klaus-Peter
中科院分区：
文献类型：
--
作者：
Pruess, Harald;Finke, Carsten;Hoeltje, Markus;Hofmann, Joerg;Klingbeil, Christine;Probst, Christian;Borowski, Kathrin;Ahnert-Hilger, Gudrun;Harms, Lutz;Schwab, Jan M.;Ploner, Christoph J.;Komorowski, Lars;Stoecker, Winfried;Dalmau, Josep;Wandinger, Klaus-Peter
确定单纯疱疹病毒性脑炎（HSE）患者中突触蛋白抗体的存在和动力学。回顾性分析了44例聚合酶链反应证实的HSE患者的神经元和突触受体抗体的存在。在原代小鼠海马神经元培养中研究患者血清的作用。在HSE过程中，44例患者中有13例（30%）检测到免疫球蛋白（IG）亚型伊加、IgG或IgM的N-甲基-d-天冬氨酸受体（NMDAR）抗体，提示继发性自身免疫机制。NMDAR抗体通常在入院时出现，但有些患者在HSE第一周后出现。抗体阳性血清导致海马神经元突触标记蛋白下调。一些HSE患者会产生针对NMDAR的伊加、IgG或IgM自身抗体。来自这些患者的血清改变神经元突触标记物的密度，表明潜在的致病性疾病修饰作用。这些发现对理解感染性疾病中的自身免疫具有意义，前瞻性研究应该揭示HSE和NMDAR抗体患者亚组是否可以从免疫治疗中获益。
To determine the presence and kinetics of antibodies against synaptic proteins in patients with herpes simplex virus encephalitis (HSE). Retrospective analysis of 44 patients with polymerase chain reaction-proven HSE for the presence of a large panel of onconeuronal and synaptic receptor antibodies. The effect of patients’ serum was studied in cultures of primary mouse hippocampal neurons. N-Methyl-d-aspartate receptor (NMDAR) antibodies of the immunoglobulin (Ig) subtypes IgA, IgG, or IgM were detected in 13 of 44 patients (30%) in the course of HSE, suggesting secondary autoimmune mechanisms. NMDAR antibodies were often present at hospital admission, but in some patients developed after the first week of HSE. Antibody-positive sera resulted in downregulation of synaptic marker proteins in hippocampal neurons. Some patients with HSE develop IgA, IgG, or IgM autoantibodies against NMDAR. Sera from these patients alter the density of neuronal synaptic markers, suggesting a potential pathogenic disease-modifying effect. These findings have implications for the understanding of autoimmunity in infectious diseases, and prospective studies should reveal whether the subgroup of patients with HSE and NMDAR antibodies may benefit from immunotherapy.
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影响因子：
2.5
作者：
Sellner, J;Dvorak, F;Meyding-Lamadè, U
通讯作者：
Meyding-Lamadè, U
影响因子：
56.3
作者：
Granerod, Julia;Ambrose, Helen E.;Crowcroft, Natasha S.
通讯作者：
Crowcroft, Natasha S.
影响因子：
48
作者：
Dalmau, Josep;Gleichman, Amy J.;Hughes, Ethen G.;Rossi, Jeffrey E.;Peng, Xiaoyu;Lai, Meizan;Dessain, Scott K.;Rosenfeld, Mynna R.;Balice-Gordon, Rita;Lynch, David R.
通讯作者：
Lynch, David R.
影响因子：
11.8
作者：
Gable, Mary S.;Sheriff, Heather;Glaser, Carol A.
通讯作者：
Glaser, Carol A.
影响因子：
9.9
作者：
Pruess, H.;Dalmau, J.;Wandinger, K. P.
通讯作者：
Wandinger, K. P.