A critical role for IL-13 in resistance to intestinal nematode infection.
A critical role for IL-13 in resistance to intestinal nematode infection.
复制标题
IL-13 在抵抗肠道线虫感染中发挥着关键作用。
作者：
A. Bancroft;A. McKenzie;R. Grencis
IL-4或IL-13基因被破坏的小鼠（IL-4 KO和IL-13 KO）对肠道线虫Trichuris muris感染敏感，而其野生型同窝出生的小鼠具有高度抗性并排出寄生虫。IL-4 KO小鼠显示T.小鼠感染，也未能产生寄生虫特异性IgG 1抗体。尽管IL-13 KO小鼠在感染早期产生减少的Th 2型应答，但它们能够在稍后的时间点产生强的Th 2型应答，并且不能调节其Ab同种型应答的幅度。这些结果证实了IL-4在T.并首次证明了IL-13在抵抗蠕虫感染中的重要作用。IL-13 KO小鼠具有与IL-4 KO小鼠不同的表型，表明IL-4和IL-13在介导对肠道蠕虫的免疫中发挥重要但不同的作用。
Mice in which either the IL-4 or the IL-13 gene has been disrupted (IL-4 KO and IL-13 KO) were susceptible to infection with the intestinal nematode Trichuris muris, whereas their wild-type littermates were highly resistant and expelled the parasite. IL-4 KO mice showed diminished Th2-type responses with T. muris infection and also failed to produce parasite-specific IgG1 Abs. Although IL-13 KO mice made reduced Th2-type responses early in infection, they were capable of generating strong Th2-type responses at later time points and were unable to regulate the magnitude of their Ab isotype response. These results confirm the importance of IL-4 in resistance to T. muris and provide the first demonstration of an important role for IL-13 in resistance to helminth infection. The IL-13 KO mouse had a separate phenotype to that of the IL-4 KO mouse, suggesting that both IL-4 and IL-13 play important yet different roles in mediating immunity to intestinal helminths.
DOI：
10.1073/pnas.88.13.5513
发表时间：
1991-07-01
影响因子：
11.1
作者：
URBAN, JF;KATONA, IM;FINKELMAN, FD
通讯作者：
FINKELMAN, FD
影响因子：
14.2
作者：
Hamid, Q;Naseer, T;Leung, DYM
通讯作者：
Leung, DYM
IL-3 和 IL-4 抗体可抑制蠕虫诱导的肠道肥大细胞增多症。
DOI：
--
发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Madden,KB;UrbanJr,JF;Ziltener,HJ;Schrader,JW;Finkelman,FD;Katona,IM
通讯作者：
Katona,IM