Termination of piroxicam treatment and the occurrence of azoxymethane-induced colon cancer in rats.
Termination of piroxicam treatment and the occurrence of azoxymethane-induced colon cancer in rats.
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吡罗昔康治疗的终止和氧化偶氮甲烷诱导的大鼠结肠癌的发生。
DOI：
10.1016/s0304-3835(99)00296-7
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发表时间：
1999
期刊：
影响因子：
9.7
通讯作者：
Pereira,MA
中科院分区：
文献类型：
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作者：
Li,H;Kramer,PM;Lubet,RA;Steele,VE;Kelloff,GJ;Pereira,MA
吡罗昔康已被证明可以预防偶氮甲烷(AOM)诱导的结肠癌，如果在促进/进展阶段给药。为了保持对结肠癌的预防，需要继续使用吡罗昔康进行治疗。雄性F344大鼠在7周龄和8周龄分别给予15 mg/kg的AOM，在第二次给药后11周开始给予吡罗昔康(200 mg/kg)。在19周和28周时，将吡罗昔康从一些大鼠的饮食中移除，并将这些动物保留到47周。其他大鼠继续接受吡罗昔康治疗，直到47周处死。在第11-47周期间使用吡罗昔康治疗可以减少结肠肿瘤的发生率。当治疗在第19周或第28周终止时，第47周的肿瘤产率没有减少。吡罗昔康治疗后1周内，变态隐窝病灶(ACF)数/只明显减少。终止治疗导致ACF复发。当吡罗昔康治疗持续到第47周时，腺瘤中的细胞凋亡增加，但在第19周或第28周早期终止治疗时并不增加。即使在治疗11-47周时，吡罗昔康对腺瘤的增殖细胞核抗原标记指数也没有影响。总而言之，终止治疗导致ACF和结肠癌的发生，这表明吡罗昔康的预防是可逆的。此外，促进细胞凋亡而不是抑制细胞增殖与预防结肠癌有关。
Piroxicam has been shown to prevent azoxymethane (AOM)-induced colon cancer when administered during the promotion/progression phase. The requirement for continued treatment with piroxicam in order to maintain prevention of colon cancer was investigated. Male F344 rats were administered 15mg/kg AOM at 7 and 8 weeks of age and started to receive piroxicam (200mg/kg) in their diet at 11 weeks after the second dose of AOM. Piroxicam was removed from the diet of some of the rats at weeks 19 and 28 and the animals were held until week 47. Other rats continued to receive piroxicam until sacrificed at week 47. Treatment with piroxicam from week 11–47 reduced the yield of colon tumors. When treatment was terminated at week 19 or 28 the yield of tumors at week 47 was not reduced. Within 1 week of the start of piroxicam treatment, the number of aberrant crypt foci (ACF)/animal was decreased. Termination of treatment resulted in the recurrence of ACF. Apoptosis in adenomas was increased when piroxicam treatment was continued to week 47 but not when treatment was terminated earlier at week 19 or 28. The proliferating cell nuclear antigen-labeling index in adenomas was not affected by piroxicam even when treatment was from week 11 to 47. In summary, termination of treatment resulted in the occurrence of ACF and colon cancer indicating that prevention by piroxicam was reversible. Furthermore, enhancement of apoptosis and not decreased cell proliferation correlated with prevention of colon cancer.
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非甾体类抗炎药对人结肠癌细胞的抗增殖作用。
DOI：
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发表时间：
1994
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Hixson,LJ;Alberts,DS;Krutzsch,M;Einsphar,J;Brendel,K;Gross,PH;Paranka,NS;Baier,M;Emerson,S;Pamukcu,R
通讯作者：
Pamukcu,R
非甾体抗炎药和分化剂对大鼠结肠异常隐窝生长的抑制
影响因子：
6.4
作者：
M. Wargovich;Chi Dai Chen;C. Harris;Eileen Yang;M. Velasco
通讯作者：
M. Velasco
阿司匹林和非甾体抗炎药对结直肠腺瘤的影响：参与诺丁汉粪便潜血筛查项目的受试者的病例对照研究。
影响因子：
--
作者：
R. Logan;J. Little;P. Hawtin;J. Hardcastle
通讯作者：
J. Hardcastle
影响因子：
4.7
作者：
M. A. Pereira;L. H. Barnes;V. Steele;G. Kelloff;R. Lubet
通讯作者：
M. A. Pereira;L. H. Barnes;V. Steele;G. Kelloff;R. Lubet