In vivo thermal ablation monitoring using ultrasound echo decorrelation imaging.
In vivo thermal ablation monitoring using ultrasound echo decorrelation imaging.
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DOI：
10.1016/j.ultrasmedbio.2013.09.007
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发表时间：
2014-01
影响因子：
2.9
通讯作者：
Mast, T. Douglas
中科院分区：
文献类型：
--
作者：
Subramanian, Swetha;Rudich, Steven M.;Alqadah, Amel;Karunakaran, Chandra Priya;Rao, Marepalli B.;Mast, T. Douglas
先前的研究表明，超声回波去相关成像可以跟踪和量化回波信号的变化，以预测体外射频消融（RFA）过程中的热损伤。在这里报道的体内研究中，评估了使用回声去相关成像作为治疗监测工具的可行性。对正常猪肝（N = 5）行射频消融术，对植入VX2肿瘤的兔肝（N = 2）行超声消融术。根据RFA和超声消融治疗过程中获得的希尔伯特变换脉冲回波数据计算回波去相关和后向散射积分。采用受试者工作特征（ROC）曲线评估回波去相关成像和综合后向散射预测消融的能力。采用回声去相关成像法测定RFA和超声消融的ROC曲线下面积（AUROC）。回声去相关成像（RFA和超声消融AUROC分别为0.832和0.776）比后向散射综合成像（AUROC分别为0.734和0.494）更准确地预测消融。
Previous work has shown ultrasound echo decorrelation imaging can track and quantify changes in echo signals to predict thermal damage during in vitro radiofrequency ablation (RFA). In the in vivo studies reported here, the feasibility of using echo decorrelation imaging as a treatment monitoring tool is assessed. RFA was performed on a normal swine liver (N = 5) and ultrasound ablation using image-ablate arrays was performed on a rabbit liver implanted with VX2 tumors (N = 2). Echo decorrelation and integrated backscatter were computed from Hilbert transformed pulse-echo data acquired during RFA and ultrasound ablation treatments. Receiver operating characteristic (ROC) curves were employed to assess the ability of echo decorrelation imaging and integrated backscatter to predict ablation. Area under the ROC curves (AUROC) was determined for RFA and ultrasound ablation using echo decorrelation imaging. Ablation was predicted more accurately using echo decorrelation imaging (AUROC 0.832 and 0.776 for RFA and ultrasound ablation respectively) than using integrated backscatter (AUROC 0.734 and 0.494).
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