The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population.
The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population.
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DOI：
10.1038/sj.bjc.6602803
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发表时间：
2005-10-17
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
高强度聚焦超声（HIFU）提供了一种潜在的非侵入性替代传统治疗。我们报告了我们的初步经验，从临床试验设计，以评估安全性和可行性的一种新型的，体外HIFU设备治疗肝脏和肾脏肿瘤在西方人口。体外超声引导Model-JC肿瘤治疗系统（中国海扶科技有限公司）已根据四个试验方案治疗了30例患者。患有肝或肾肿瘤的患者在全身麻醉下接受单次治疗性HIFU治疗。治疗后12天的磁共振成像提供了反应评估。这些患者被细分为单独进行进一步成像的患者或接受肿瘤手术切除的患者，这使得放射学和组织学评估成为可能。HIFU暴露导致27例可评价患者中的25例（93%）出现离散消融区。肝脏肿瘤的消融比肾脏肿瘤更一致（100 vs 67%，放射学评估）。与更具侵入性的技术相比，不良事件特征是有利的。HIFU治疗西方人群的肝脏和肾脏肿瘤是安全可行的。这些发现对未来的无创图像引导肿瘤消融术具有重要意义。
High-intensity focused ultrasound (HIFU) provides a potential noninvasive alternative to conventional therapies. We report our preliminary experience from clinical trials designed to evaluate the safety and feasibility of a novel, extracorporeal HIFU device for the treatment of liver and kidney tumours in a Western population. The extracorporeal, ultrasound-guided Model-JC Tumor Therapy System (HAIFU™ Technology Company, China) has been used to treat 30 patients according to four trial protocols. Patients with hepatic or renal tumours underwent a single therapeutic HIFU session under general anaesthesia. Magnetic resonance imaging 12 days after treatment provided assessment of response. The patients were subdivided into those followed up with further imaging alone or those undergoing surgical resection of their tumours, which enabled both radiological and histological assessment. HIFU exposure resulted in discrete zones of ablation in 25 of 27 evaluable patients (93%). Ablation of liver tumours was achieved more consistently than for kidney tumours (100 vs 67%, assessed radiologically). The adverse event profile was favourable when compared to more invasive techniques. HIFU treatment of liver and kidney tumours in a Western population is both safe and feasible. These findings have significant implications for future noninvasive image-guided tumour ablation.
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影响因子：
2.9
作者：
HILL, CR;RIVENS, I;TERHAAR, GR
通讯作者：
TERHAAR, GR
影响因子：
19.7
作者：
Shibata, T;Iimuro, Y;Konishi, K
通讯作者：
Konishi, K
影响因子：
78.5
作者：
Kennedy, JE
通讯作者：
Kennedy, JE
DOI：
10.1085/jgp.26.2.179
发表时间：
1942-11-20
期刊：
The Journal of general physiology
影响因子：
--
作者：
Lynn JG;Zwemer RL;Chick AJ;Miller AE
通讯作者：
Miller AE
影响因子：
19.7
作者：
LIVRAGHI, T;GIORGIO, A;ZUCCHI, A
通讯作者：
ZUCCHI, A