Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites.
Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites.
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DOI：
10.1038/s41598-021-83680-5
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发表时间：
2021-02-18
影响因子：
4.6
通讯作者：
Takada M
中科院分区：
文献类型：
--
作者：
Takata Y;Nakagawa H;Ninomiya T;Yamanaka H;Takada M
在灵长类动物中，位于额叶运动相关区域的大型V层锥体神经元向脊髓发送各种运动命令，产生皮质脊髓束，用于执行熟练的运动行为。然而，鲜为人知的是，这种锥体神经元的形态多样性的地区。在这里，我们表明，在背侧运动前皮质（PMD）的大V层锥体神经元的基底树突的结构是不同的，在其他地区，包括初级运动皮质，辅助运动区，和腹侧运动前皮质。在PMd中，不仅基底树突的复杂性（树枝化），即，总的树突长度和分支数量，发育不良，而且树突棘的密度也很低，与其他运动相关区域相比。关于三种树突棘类型的分布，我们发现，薄型（更不成熟）的棘是突出的PMD相比，蘑菇型（更成熟）的棘，而薄和蘑菇型的棘在其他地区。基底树突的不同形态特征可能反映了运动相关区域中大的V层锥体神经元内运动信息处理的不同模式。
In primates, large layer V pyramidal neurons located in the frontal motor-related areas send a variety of motor commands to the spinal cord, giving rise to the corticospinal tract, for execution of skilled motor behavior. However, little is known about the morphological diversity of such pyramidal neurons among the areas. Here we show that the structure of basal dendrites of the large layer V pyramidal neurons in the dorsal premotor cortex (PMd) is different from those in the other areas, including the primary motor cortex, the supplementary motor area, and the ventral premotor cortex. In the PMd, not only the complexity (arborization) of basal dendrites, i.e., total dendritic length and branching number, was poorly developed, but also the density of dendritic spines was so low, as compared to the other motor-related areas. Regarding the distribution of the three dendritic spine types identified, we found that thin-type (more immature) spines were prominent in the PMd in comparison with stubby- and mushroom-type (more mature) spines, while both thin- and stubby-type spines were in the other areas. The differential morphological features of basal dendrites might reflect distinct patterns of motor information processing within the large layer V pyramidal neurons in individual motor-related areas.
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