Cardiovascular cell therapy and endogenous repair.
Cardiovascular cell therapy and endogenous repair.
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DOI：
10.1111/j.1463-1326.2008.00937.x
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发表时间：
2008-11
影响因子：
5.8
通讯作者：
Zenovich, A. G.
中科院分区：
文献类型：
--
作者：
Taylor, D. A.;Zenovich, A. G.
心血管疾病（CVD）超过感染和癌症，成为死亡的主要原因。仅在美国，每年约有一百万人患有急性心肌梗死（AMI）。随着心血管疾病危险因素（如高血压、肥胖和2型糖尿病）患病率的上升，年轻人的心血管疾病也在增加。幸运的是，现有的治疗方法已经改善了AMI后的死亡率，但反过来又增加了AMI后心力衰竭（HF）的患病率。在美国，每年诊断出大约50万新发HF病例。在未来25年内，预计美国65岁以上人群中高达15%的人患有HF。预防/逆转动脉粥样硬化、预防AMI后HF和一旦HF发生就停止进行性功能恶化的治疗干预都是需要的。细胞疗法--无论是通过外源性递送还是通过内源性细胞动员--都可以做到这一点，部分原因是提高了身体的修复能力。到目前为止，主要是骨髓或血液来源的细胞已被用于AMI后，以防止左心室功能障碍，骨骼肌成肌细胞已被移植到失败的心肌。临床前研究旨在用骨髓前体预防/逆转动脉粥样硬化，并最终用基于细胞的生物人工构建体取代衰竭的心脏。
Cardiovascular disease (CVD) exceeds infection and cancer as the leading cause of death. In the USA alone, approximately a million individuals suffer an acute myocardial infarction (AMI) annually. As the prevalence of CVD risk factors (e.g. hypertension, obesity and type 2 diabetes) rises, CVD is increasing in younger individuals. Fortunately, existing therapies have improved post-AMI mortality, but in turn have increased the prevalence of post-AMI heart failure (HF). Approximately half-a-million new HF cases are diagnosed each year in the USA. In the next 25 years, up to 15% of the population over the age of 65 in the USA is projected to have HF. Therapeutic interventions that prevent/reverse atherosclerosis, prevent post-AMI HF and halt the progressive functional deterioration once HF occurs are all needed. Cell therapy – either via exogenous delivery or by endogenous mobilization of cells – may be able to do so, in part, by improving the body’s capacity for repair. To date, primarily bone marrow- or blood-derived cells have been utilized after AMI to prevent left ventricular dysfunction, and skeletal myoblasts have been transplanted into failing myocardium. Preclinical studies are directed at prevention/reversal of atherosclerosis with bone marrow precursors, and ultimately at replacing failing heart with a cell-based bioartificial construct.
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影响因子：
64.8
作者：
Anversa, P;Nadal-Ginard, B
通讯作者：
Nadal-Ginard, B
影响因子：
15.9
作者：
Gallagher, Katherine A.;Liu, Zhao-Jun;Velazquez, Omaida C.
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Velazquez, Omaida C.
影响因子：
82.9
作者：
Aicher, A;Heeschen, C;Dimmeler, S
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Dimmeler, S
影响因子：
8.9
作者：
McCue, Jonathan D.;Swingen, Cory;Taylor, Doris A.
通讯作者：
Taylor, Doris A.
影响因子：
37.8
作者：
Menasche, Philippe;Alfieri, Ottavio;Hagege, Albert A.
通讯作者：
Hagege, Albert A.