Gut microbial composition in patients with psoriasis.
Gut microbial composition in patients with psoriasis.
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DOI：
10.1038/s41598-018-22125-y
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发表时间：
2018-02-28
影响因子：
4.6
通讯作者：
Chenoll E
中科院分区：
文献类型：
--
作者：
Codoñer FM;Ramírez-Bosca A;Climent E;Carrión-Gutierrez M;Guerrero M;Pérez-Orquín JM;Horga de la Parte J;Genovés S;Ramón D;Navarro-López V;Chenoll E
在过去的5-10年里，肠道微生物组与不同肠道疾病的相关性已经被揭示出来。最近的研究结果表明肠道微生物组对某些皮肤病如特应性皮炎的影响。然而，关于其他皮肤病如牛皮癣的数据有限。这是首次尝试揭示银屑病患者的肠道微生物组组成，包括一组斑块状银屑病患者的前瞻性研究，分析他们的肠道微生物组以及微生物组组成与细菌易位之间的关系。通过使用MiSeq平台（Illumina Inc，San Diego）的16 s rRNA大规模测序获得52名银屑病患者（PASI评分≥6）的队列的微生物组，每个样本平均有85，000个序列。对肠道微生物组和肠型的研究首次显示了一种特定的“银屑病核心肠道微生物组”，其明显不同于健康人群中存在的微生物组。此外，与其他肠型患者（肠型1为16%;肠型3为21%）相比，那些被归类为肠型2的银屑病患者倾向于经历更频繁的细菌易位和更高的炎症状态（71%）。
Since the last 5–10 years the relevance of the gut microbiome on different intestinal illnesses has been revealed. Recent findings indicate the effect of gut microbiome on certain dermatological diseases such as atopic dermatitis. However, data on other skin diseases such as psoriasis are limited. This is the first time attempting to reveal the gut microbiome composition of psoriatic patients with a prospective study including a group of patients with plaque psoriasis, analyzing their gut microbiome and the relationship between the microbiome composition and bacterial translocation. The microbiome of a cohort of 52 psoriatic patients (PASI score ≥6) was obtained by 16s rRNA massive sequencing with MiSeq platform (Illumina inc, San Diego) with an average of 85,000 sequences per sample. The study of the gut microbiome and enterotype shows from the first time a specific “psoriatic core intestinal microbiome” that clearly differs from the one present in healthy population. In addition, those psoriatic patients classified as belonging to enterotype 2 tended to experience more frequent bacterial translocation and higher inflammatory status (71%) than patients with other enterotypes (16% for enterotype 1; and 21% for enterotype 3).
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影响因子：
14.9
作者：
Klindworth A;Pruesse E;Schweer T;Peplies J;Quast C;Horn M;Glöckner FO
通讯作者：
Glöckner FO
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
24.5
作者：
Dao, Maria Carlota;Everard, Amandine;Clement, Karine
通讯作者：
Clement, Karine
影响因子：
5.9
作者：
Vinolo MA;Rodrigues HG;Nachbar RT;Curi R
通讯作者：
Curi R
影响因子：
6.5
作者：
Mallbris, L;Larsson, P;Ståhle, M
通讯作者：
Ståhle, M