The Use of Chromatin Precipitation Coupled to DNA Sequencing (ChIP-Seq) for the Analysis of Zta Binding to the Human and EBV Genome.
The Use of Chromatin Precipitation Coupled to DNA Sequencing (ChIP-Seq) for the Analysis of Zta Binding to the Human and EBV Genome.
复制标题
使用染色质沉淀结合 DNA 测序 (ChIP-Seq) 分析 Zta 与人类和 EBV 基因组的结合。
DOI：
10.1007/978-1-4939-6655-4_14
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Godfrey A
中科院分区：
文献类型：
--
作者：
Godfrey A
确定哪些转录机制的组成部分与病毒和细胞基因组相关，以及在病毒生命周期的特定阶段如何变化，对于理解与原发感染，潜伏期和疾病相关的不同转录程序如何建立以及它们如何在病毒裂解复制周期的启动和执行期间重新编程至关重要。与下一代DNA测序（ChIP-Seq）相关的染色质沉淀允许蛋白质与DNA的相互作用在病毒和细胞基因组中进行映射。这可以应用于病毒和细胞转录因子，辅激活子和辅阻遏子，修饰的组蛋白和染色质的调节剂。
Determining which components of the transcription machinery associate with the viral and cellular genome, and how this changes at specific stages of the viral life cycle is paramount to understanding how the distinct transcriptional programs associated with primary infection, latency, and disease are established and how they are reprogrammed during initiation and execution of the viral lytic replication cycle. Chromatin precipitations linked to next generation DNA sequencing (ChIP-Seq) allow for the interactions of proteins with DNA to be mapped across both viral and cellular genomes. This can be applied to viral and cellular transcription factors, coactivators and corepressors, modified histones, and modulators of chromatin.
影响因子：
30.3
作者：
Arvey A;Tempera I;Tsai K;Chen HS;Tikhmyanova N;Klichinsky M;Leslie C;Lieberman PM
通讯作者：
Lieberman PM
影响因子：
3.7
作者：
Holdorf MM;Cooper SB;Yamamoto KR;Miranda JJ
通讯作者：
Miranda JJ
DOI：
10.1073/pnas.1318948111
发表时间：
2014-04-29
影响因子：
11.1
作者：
Kellis, Manolis;Wold, Barbara;Hardison, Ross C.
通讯作者：
Hardison, Ross C.