Rheumatologic manifestations of sarcoidosis.
Rheumatologic manifestations of sarcoidosis.
复制标题
结节病的风湿病表现。
DOI：
10.1055/s-0030-1262214
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发表时间：
2010-08
影响因子：
3.2
通讯作者：
Baughman RP
中科院分区：
文献类型：
--
作者：
Sweiss NJ;Patterson K;Sawaqed R;Jabbar U;Korsten P;Hogarth K;Wollman R;Garcia JG;Niewold TB;Baughman RP
结节病是一种全身性、临床异质性疾病，其特征是出现肉芽肿。任何器官系统都可能受累，患者可能出现多种风湿病症状。目前还没有美国食品和药物管理局批准的治疗结节病的疗法。诊断结节病变得具有挑战性，特别是当其并发症导致患者的症状与其他疾病相似时，包括多发性肌炎、干燥综合征或血管炎。本综述概述了结节病的病因和相关生物标志物。然后，我们详细描述了结节病的风湿病表现，并根据结节性关节炎患者当前的临床证据提出了治疗方案。讨论将集中于结节性关节炎、结节病骨质受累和结节性肌病患者的特征性表现。还描述了有时与结节病共存的关节炎病症。我们介绍两例伴有风湿病表现的结节病病例。我们的目的是鼓励采用多学科、转化方法来应对理解和治疗结节病的挑战和困难。
Sarcoidosis is a systemic, clinically heterogeneous disease characterized by the development of granulomas. Any organ system can be involved, and patients may present with any number of rheumatologic symptoms. There are no U.S. Food and Drug Administration–approved therapies for the treatment of sarcoidosis. Diagnosing sarcoidosis becomes challenging, particularly when its complications cause patients’ symptoms to mimic other conditions, including polymyositis, Sjögren syndrome, or vasculitis. This review presents an overview of the etiology of and biomarkers associated with sarcoidosis. We then provide a detailed description of the rheumatologic manifestations of sarcoidosis and present a treatment algorithm based on current clinical evidence for patients with sarcoid arthritis. The discussion will focus on characteristic findings in patients with sarcoid arthritis, osseous involvement in sarcoidosis, and sarcoid myopathy. Arthritic conditions that sometimes coexist with sarcoidosis are described as well. We present two cases of sarcoidosis with rheumatologic manifestations. Our intent is to encourage a multidisciplinary, translational approach to meet the challenges and difficulties in understanding and treating sarcoidosis.
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影响因子：
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