Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease.
Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease.
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宏基因组测序揭示了微生物群及其与牙周病相关的功能潜力。
DOI：
10.1038/srep01843
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发表时间：
2013
影响因子：
4.6
通讯作者：
Zhao F
中科院分区：
文献类型：
--
作者：
Wang J;Qi J;Zhao H;He S;Zhang Y;Wei S;Zhao F
虽然已经尝试揭示细菌与人类健康之间的关系，但对与口腔疾病相关的微生物群落的种类和功能知之甚少。在这项研究中，我们报告了16个宏基因组样本的测序，这些样本是从代表四种牙周状态的牙拭子和牙菌斑中收集的。深入了解与牙周健康和疾病相关的微生物群落结构和代谢变化。我们观察到社区结构和疾病状态之间存在很强的相关性，并描述了一个核心疾病相关社区。许多功能基因和代谢途径，包括细菌的趋化性和聚糖的生物合成在牙周病的微生物组中过度表达。大量的新物种和基因被确定在宏基因组组装。我们的研究丰富了对口腔微生物组的理解，并揭示了微生物对牙菌斑和口腔疾病的形成和继承的贡献。
Although attempts have been made to reveal the relationships between bacteria and human health, little is known about the species and function of the microbial community associated with oral diseases. In this study, we report the sequencing of 16 metagenomic samples collected from dental swabs and plaques representing four periodontal states. Insights into the microbial community structure and the metabolic variation associated with periodontal health and disease were obtained. We observed a strong correlation between community structure and disease status, and described a core disease-associated community. A number of functional genes and metabolic pathways including bacterial chemotaxis and glycan biosynthesis were over-represented in the microbiomes of periodontal disease. A significant amount of novel species and genes were identified in the metagenomic assemblies. Our study enriches the understanding of the oral microbiome and sheds light on the contribution of microorganisms to the formation and succession of dental plaques and oral diseases.
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影响因子：
14.9
作者：
Kanehisa M;Araki M;Goto S;Hattori M;Hirakawa M;Itoh M;Katayama T;Kawashima S;Okuda S;Tokimatsu T;Yamanishi Y
通讯作者：
Yamanishi Y
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
7
作者：
Li, Ruiqiang;Zhu, Hongmei;Wang, Jun
通讯作者：
Wang, Jun
影响因子：
3.2
作者：
KATO, T;TAKAHASHI, N;KURAMITSU, HK
通讯作者：
KURAMITSU, HK
影响因子：
3.1
作者：
Dorn, BR;Leung, KP;Progulske-Fox, A
通讯作者：
Progulske-Fox, A