Plasma appearance of labeled beta-carotene, lutein, and retinol in humans after consumption of isotopically labeled kale.
Plasma appearance of labeled beta-carotene, lutein, and retinol in humans after consumption of isotopically labeled kale.
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人类食用同位素标记的羽衣甘蓝后，血浆中出现标记的 β-胡萝卜素、叶黄素和视黄醇。
DOI：
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发表时间：
2005
影响因子：
6.5
通讯作者：
B. Clevidence
中科院分区：
文献类型：
--
作者：
J. Novotny;A. Kurilich;S. Britz;B. Clevidence
通过用13C标记羽衣甘蓝中的营养物质，喂给7名成年志愿者，并分析了一系列血浆样本中标记的叶黄素、β-胡萝卜素和视黄醇，研究了甘蓝类胡萝卜素的生物利用度。标记类胡萝卜素的摄入量为34微摩尔的β-胡萝卜素和33微摩尔的叶黄素。计算峰值血药浓度、血药浓度-时间曲线下面积(AUC)和血药浓度峰值恢复剂量百分比。[13C]叶黄素、[13C]β-胡萝卜素和[13C]视黄醇的平均血浆峰值浓度分别为0.38、0.068和0.079微米。[13C]叶黄素、[13C]β-胡萝卜素和[13C]视黄醇的平均AUC值(28天以上)分别为42.8、13.6、13.2微米小时。在血浆峰值浓度下，[13C]叶黄素、[13C]β-胡萝卜素和[13C]视黄醇的回收率分别为3.6%、0.7%和0.7%。基线血浆视黄醇水平与[13C]视黄醇血浆反应呈正相关。这种关系可能是通过某些方面的β-胡萝卜素吸收或通过剂量后和内源性类维A酸代谢的共同途径来调节的。
The bioavailability of carotenoids from kale was investigated by labeling nutrients in kale with 13C, feeding the kale to seven adult volunteers, and analyzing serial plasma samples for labeled lutein, beta-carotene, and retinol. Ingested doses of labeled carotenoids were 34 micromol for beta-carotene and 33 micromol for lutein. Peak plasma concentrations, areas under the plasma concentration-time curves (AUCs), and percentages of dose recovered at peak plasma concentrations were calculated. Average peak plasma concentrations were 0.38, 0.068, and 0.079 microM for [13C]lutein, [13C]beta-carotene, and [13C]retinol, respectively. Average AUC values (over 28 days) were 42.8, 13.6, 13.2 microM h for [13C]lutein, [13C]beta-carotene, and [13C]retinol, respectively. Percentages of dose recovered at peak plasma concentrations were 3.6, 0.7, and 0.7% for [13C]lutein, [13C]beta-carotene, and [13C]retinol, respectively. A positive relationship was observed between baseline plasma retinol levels and [13C]retinol plasma response. It is possible that this relationship was mediated either through some aspect of beta-carotene absorption or via the common pathways of metabolism for postdose and endogenous retinoid.
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DOI：
10.1093/ajcn/71.6.1545
发表时间：
2000-06
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
S. Hickenbottom;J. Follett;Yumei Lin;S. Dueker;B. Burri;T. Neidlinger;A. Clifford
通讯作者：
S. Hickenbottom;J. Follett;Yumei Lin;S. Dueker;B. Burri;T. Neidlinger;A. Clifford
DOI：
10.1093/ajcn/62.6.1448s
发表时间：
1995-12
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
D. Snodderly
通讯作者：
D. Snodderly
营养学数学模型：构建β-胡萝卜素代谢动力学的生理室模型。
DOI：
10.1016/s1043-4526(08)60019-4
发表时间：
1996
期刊：
Advances in food and nutrition research.
影响因子：
--
作者：
Novotny,JA;Zech,LA;Furr,HC;Dueker,SR;Clifford,AJ
通讯作者：
Clifford,AJ
9-顺式-β-胡萝卜素在人体吸收过程中顺反异构化的证据。
DOI：
10.1093/ajcn/64.2.177
发表时间：
1996
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
You,CS;Parker,RS;Goodman,KJ;Swanson,JE;Corso,TN
通讯作者：
Corso,TN
成年志愿者 β-胡萝卜素代谢动态的区室分析。
影响因子：
6.5
作者：
Novotny,JA;Dueker,SR;Zech,LA;Clifford,AJ
通讯作者：
Clifford,AJ