Control by the brain of vitamin A homeostasis.
Control by the brain of vitamin A homeostasis.
复制标题
DOI：
10.1016/j.isci.2023.107373
复制
发表时间：
2023-08-18
期刊：
影响因子：
5.8
通讯作者：
Mccaffery, Peter
中科院分区：
文献类型：
--
作者：
Imoesi, Peter I.;Olarte-Sanchez, Cristian M.;Croce, Lorenzo;Blaner, William S.;Morgan, Peter J.;Heisler, Lora;Mccaffery, Peter
维生素A是脊椎动物维持体内稳态平衡所必需的微量营养素;然而，对这种平衡的控制知之甚少。这项研究调查了下丘脑，一个关键的整合性大脑区域，是否调节肝脏和循环中的维生素A水平。将维生素A以视黄醇或视黄酸的形式立体定向注射到大鼠脑的第三脑室中。或者，通过视黄醇结合蛋白4（Rbp 4）基因敲低改变小鼠下丘脑中的类维生素A。这导致控制维生素A体内平衡的肝脏蛋白质以及肝脏和循环中的维生素A本身发生快速变化。在小鼠下丘脑弓状核区域长时间破坏Rbp 4改变了肝脏中的视黄醇水平。这支持了大脑可能感知类维生素A并影响全身维生素A稳态的概念，可能具有“维生素抑制”作用。维生素A在血液中保持恒定的浓度，但不知道下丘脑伸长细胞如何具有感知维生素A的潜力维生素A应用于下丘脑会改变全身维生素A的分布这揭示了大脑在控制维生素A体内平衡中的可能作用自然科学;生物科学;生理学;神经科学;内分泌学。
Vitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance. This study investigated whether the hypothalamus, a key integrative brain region, regulates vitamin A levels in the liver and circulation. Vitamin A in the form of retinol or retinoic acid was stereotactically injected into the 3rd ventricle of the rat brain. Alternatively, retinoids in the mouse hypothalamus were altered through retinol-binding protein 4 (Rbp4) gene knockdown. This led to rapid change in the liver proteins controlling vitamin A homeostasis as well as vitamin A itself in liver and the circulation. Prolonged disruption of Rbp4 in the region of the arcuate nucleus of the mouse hypothalamus altered retinol levels in the liver. This supports the concept that the brain may sense retinoids and influence whole-body vitamin A homeostasis with a possible “vitaminostatic” role. Vitamin A is kept at a constant concentration in the blood but it is unknown how Hypothalamic tanycytes have the potential to sense vitamin A Vitamin A application to the hypothalamus alters systemic vitamin A distribution This reveals a possible role for the brain in the control of vitamin A homeostasis Natural sciences; Biological sciences; Physiology; Neuroscience; Endocrinology.
登录
查看更多内容
影响因子：
4.8
作者：
KURLANDSKY, SB;GAMBLE, MV;BLANER, WS
通讯作者：
BLANER, WS
影响因子：
3.3
作者：
Krezel, W;Kastner, P;Chambon, P
通讯作者：
Chambon, P
影响因子：
8
作者：
Li, Yang;Wongsiriroj, Nuttaporn;Blaner, William S
通讯作者：
Blaner, William S
影响因子：
4.7
作者：
Shearer, Kirsty D.;Stooney, Patrick N.;McCaffery, Peter
通讯作者：
McCaffery, Peter
DOI：
10.1111/j.1432-1033.1976.tb10390.x
发表时间：
1976-01-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
COGAN, U;KOPELMAN, M;SHINITZKY, M
通讯作者：
SHINITZKY, M