Ambient temperature and risk of first primary basal cell carcinoma: A nationwide United States cohort study.
Ambient temperature and risk of first primary basal cell carcinoma: A nationwide United States cohort study.
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DOI：
10.1016/j.jphotobiol.2015.04.025
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发表时间：
2015-07
影响因子：
5.4
通讯作者：
Cahoon, Elizabeth K.
中科院分区：
文献类型：
--
作者：
Freedman, D. Michal;Kitahara, Can M.;Linet, Martha S.;Alexander, Bruce H.;Neta, Gila;Little, Mark P.;Cahoon, Elizabeth K.
地球表面正在变暖，动物研究表明，较高的温度会促进紫外线辐射（UVR）皮肤癌的发生。然而，没有长期温度暴露与基底细胞癌（BCC）风险的人群研究。我们将美国放射技术人员队列中的平均夏季环境温度（基于气象站数据）和基于卫星的UVR估计与自我报告的终身住所联系起来。我们使用Cox比例风险回归评估了五分位数中时间依赖的平均夏季环境温度（20年滞后）与白人BCC之间的关系。风险根据时间依赖的滞后平均寿命紫外线辐射和户外时间、体重指数、眼睛颜色和性别（出生队列的基线风险分层）进行调整。在中位19.4年的随访期间，我们发现了3556例BCC病例。温度与BCC之间的风险无显著趋势。然而，BCC风险在温度的第四个五分位数最高(Q4 vs. Q1；风险比(HR)=1.18；95%置信区间(CI) = 1.06-1.31, p-trend =0.09)。BCC风险与平均终生环境UVR暴露密切相关(Q5 vs. Q1; HR = 1.54 （95% CI = 1.35-1.75, p-trend= <0.001）。未来对温度和BCC风险的研究应包括广泛的紫外线辐射和温度值，以及改进的暴露于温度和紫外线辐射的指标。
The Earth's surface is warming and animal studies have shown higher temperatures promote ultraviolet radiation (UVR) skin carcinogenesis. There are, however, no population studies of long-term temperature exposure and basal cell carcinoma (BCC) risk. We linked average lifetime summer ambient temperatures (based on weather station data) and satellite-based UVR estimates to self-reported lifetime residences in the U.S. Radiologic Technologists' cohort. We assessed the relationship between time-dependent average lifetime summer ambient temperature (20-year lag) in quintiles and BCC in whites, using Cox proportional hazards regression. Risks were adjusted for time-dependent lagged average lifetime UVR and time outdoors, body mass index, eye color, and sex (baseline hazard stratified on birth cohort). During a median 19.4 years follow-up, we identified 3,556 BCC cases. There was no significant trend in risk between temperature and BCC. However, BCC risk was highest in the fourth quintile of temperature (Q4 vs. Q1; hazards ratio (HR)=1.18; 95% confidence interval (CI) = 1.06–1.31, p-trend =0.09). BCC risk was strongly related to average lifetime ambient UVR exposure (Q5 vs. Q1; HR = 1.54 (95% CI = 1.35–1.75, p-trend= <0.001)). Future studies of temperature and BCC risk should include a broad range of UVR and temperature values, along with improved indicators of exposure to temperatures and UVR.
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影响因子：
8
作者：
Boukamp, P;Popp, S;Fusenig, NE
通讯作者：
Fusenig, NE
影响因子：
--
作者：
FREEMAN, RG;KNOX, JM
通讯作者：
KNOX, JM
DOI：
10.1016/s1011-1344(01)00198-1
发表时间：
2001-10-01
影响因子：
5.4
作者：
Armstrong, BK;Kricker, A
通讯作者：
Kricker, A
影响因子：
1.7
作者：
Meibodi, Naser Tayyebi;Maleki, Masood;Nahidi, Yalda
通讯作者：
Nahidi, Yalda
DOI：
10.1093/jnci/88.24.1848
发表时间：
1996-12-18
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Karagas, MR;McDonald, JA;Stevens, M
通讯作者：
Stevens, M