A Prospective Comparison of How the Level of Response to Alcohol and Impulsivity Relate to Future DSM-IV Alcohol Problems in the COGA Youth Panel.
A Prospective Comparison of How the Level of Response to Alcohol and Impulsivity Relate to Future DSM-IV Alcohol Problems in the COGA Youth Panel.
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DOI：
10.1111/acer.13407
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Bucholz K
中科院分区：
文献类型：
--
作者：
Schuckit MA;Smith TL;Danko G;Anthenelli R;Schoen L;Kawamura M;Kramer J;Dick DM;Neale Z;Kuperman S;McCutcheon V;Anokhin AP;Hesselbrock V;Hesselbrock M;Bucholz K
酒精问题反映了环境和遗传特征，这些特征通常通过内在表型起作用，如对酒精的低水平反应(低LR)和更高的冲动。已经研究了这些先前存在的特征与酒精问题的关系，但很少有分析在同一模型中同时包括低LR和冲动。我们从酒精中毒遗传学合作研究(COGA)的1,028名预期青年样本中提取了预期数据。在时间1(18岁)时，这些饮酒但非酒精依赖的男性和女性完成了Barratt冲动量表和关于饮酒前5次所需饮料的酒精影响问卷的自我报告(SRE5-LR)。两年后，他们报告了同龄人的饮酒模式(同龄人)，他们自己的饮酒预期(Expect)，以及他们为了应对压力而饮酒(COPE)。随后，在时间3，参与者报告了从时间2起的两年内经历的多达11个DSM-IV酒精标准项目(ALC试验)。数据分析采用结构方程模型(SEM)。在扫描电子显微镜中，基线SRE5-LR和冲动性之间的相关性很弱，在预测以后的ALC问题上没有交互作用。LR直接与Time 3 ALC Probe和Peer相关联，但没有直接的路径可供预期，部分中介通过Peer to Expect和Via cope到ALC Probe。冲动与ALC先证者或同伴没有直接关系，但与期望和应对直接相关，对ALC先证者的影响也通过预期和应对进行操作。与时间3 ALC探测相关的低LR和冲动性通过略有不同的路径。为了缓解未来的酒精问题，基于教育和咨询的方法可能会受益于强调不同的潜在媒介，即低LRS和高冲动或两者兼有的年轻人的不良酒精结果。
Alcohol problems reflect both environmental and genetic characteristics that often operate through endophenotypes like low levels of response (low LRs) to alcohol and higher impulsivity. Relationships of these preexisting characteristics to alcohol problems have been studied, but few analyses have included both low LR and impulsivity in the same model. We extracted prospective data from 1,028 participants in the Prospective Youth Sample of the Collaborative Study for the Genetics of Alcoholism (COGA). At Time 1 (age 18) these drinking but non-alcohol dependent males and females completed the Barratt Impulsivity Scale and the Self Report of the Effects of Alcohol Questionnaire regarding drinks required for effects the first 5 times of drinking (SRE5-LR). Two years later, they reported perceived drinking patterns of peers (PEER), their own alcohol expectancies (EXPECT), and their drinking to cope with stress (COPE). Subsequently, at Time 3, participants reported numbers of up to 11 DSM-IV alcohol criterion items experienced in the 2 years since Time 2 (ALC PROBS). Data were analyzed using Structural Equation Modeling (SEM). In the SEM, Baseline SRE5-LR and impulsivity were weakly related and did not interact in predicting later ALC PROBS. LR was directly linked to Time 3 ALC PROBS, and to PEER, but had no direct path to EXPECT, with partial mediation to ALC PROBS through PEER to EXPECT and via COPE. Impulsivity did not relate directly to ALC PROBS or PEER, but was directly related to EXPECT and COPE, with effects on ALC PROBS also operating through EXPECT and COPE. Low LRs and impulsivity related to Time 3 ALC PROBS through somewhat different paths. Education- and counseling-based approaches to mitigate future alcohol problems may benefit from emphasizing different potential mediators of adverse alcohol outcomes for youth with low LRs versus those with high impulsivity or both characteristics.
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影响因子：
0.9
作者：
Dick, Danielle M.;Aliev, Fazil;Latendresse, Shawn;Porjesz, Bernice;Schuckit, Marc;Rangaswamy, Madhavi;Hesselbrock, Victor;Edenberg, Howard;Nurnberger, John, Jr.;Agrawal, Arpana;Bierut, Laura;Wang, Jen;Bucholz, Kathy;Kuperman, Samuel;Kramer, John
通讯作者：
Kramer, John
影响因子：
3.4
作者：
Dick DM;Cho SB;Latendresse SJ;Aliev F;Nurnberger JI Jr;Edenberg HJ;Schuckit M;Hesselbrock VM;Porjesz B;Bucholz K;Wang JC;Goate A;Kramer JR;Kuperman S
通讯作者：
Kuperman S
影响因子：
--
作者：
Kendler, KS;Prescott, CA;Neale, MC
通讯作者：
Neale, MC
影响因子：
7.6
作者：
CARVER, CS;SCHEIER, MF;WEINTRAUB, JK
通讯作者：
WEINTRAUB, JK
DOI：
10.1207/s15328007sem0902_1
发表时间：
2002-01-01
影响因子：
6
作者：
Little, TD;Cunningham, WA;Widaman, KF
通讯作者：
Widaman, KF