Association between Maternal and Foetal Erythrocyte Fatty Acid Profiles and Birth Weight.
Association between Maternal and Foetal Erythrocyte Fatty Acid Profiles and Birth Weight.
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DOI：
10.3390/nu10040402
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发表时间：
2018-03-23
期刊：
影响因子：
5.9
通讯作者：
Manco M
中科院分区：
文献类型：
--
作者：
Cinelli G;Fabrizi M;Ravà L;Signore F;Vernocchi P;Semeraro M;Vallone C;Lanciotti R;Ciofi Degli Atti M;Manco M
胎儿的正常发育对于确保后代良好的健康状况至关重要。母亲膳食脂肪酸 (FA) 的质量和数量会影响生长。该研究旨在：（1）调查母体/胎儿血脂状况与出生体重（BW）的关系； (2) 比较小于胎龄儿、适当胎龄儿和大于胎龄儿（SGA、AGA 和 LGA）的这些资料。使用气相色谱分析法对 607 对母婴（316 名男性，52.1%）的红细胞膜中的 FA 进行了测量。在分位数回归中，体重与母体亚油酸（LA；C18：2，n-6；系数：18.66；p = 0.010）、花生四烯酸（AA；C20：4，n-6；系数：11.35；p = 0.007）、二十二碳六烯酸（DHA；C22：6，n-3；系数：发现了 FA（系数：29.73；p = 0.007）、多不饱和 FA（系数：8.55；p = 0.001）、胎儿 DHA（系数：-22.82；p = 0.037）和饱和 FA（系数：-65.41；p = 0.002）。与 AGA 婴儿相比，SGA 婴儿中母体（p = 0.000；p = 0.017）和胎儿（p = 0.009；p = 0.002）的肉豆蔻酸（C14:0）和十五烷酸（C15:0）以及母体芥酸（C22:1，n-9；p = 0.026）的水平较高。相反，AGA 婴儿的母亲 LA、AA 和 omega 6 FA 水平较高（分别为 p = 0.037；p = 0.003；p = 0.026）。母体和胎儿的多不饱和脂肪酸和欧米伽 6 脂肪酸水平与体重呈正相关，而富含饱和脂肪酸和芥酸的血脂可能会影响 SGA 的风险。
Regular foetal development is crucial for assuring good health status in the offspring. The quality and quantity of maternal dietary fatty acids (FAs) can affect growth. The study aimed to: (1) investigate the association of maternal/foetal lipid profiles with birth weight (BW); and (2) compare these profiles in small, appropriate, and large for gestational age (SGA, AGA, and LGA) infants. FAs were measured in erythrocyte membranes using gas chromatography analysis in 607 mother–infant pairs (316 males, 52.1%). In the quantile regression, a significant association between BW and levels of maternal linoleic acid (LA; C18:2, n-6; coefficient: 18.66; p = 0.010), arachidonic acid (AA; C20:4, n-6; coefficient: 11.35; p = 0.007), docosahexaenoic acid (DHA; C22:6, n-3; coefficient: 29.73; p = 0.007), polyunsaturated FAs (coefficient: 8.55; p = 0.001), foetal DHA (coefficient: −22.82; p = 0.037), and saturated FAs (coefficient: −65.41; p = 0.002) was found. Myristic (C14:0) and pentadecanoic acids (C15:0), both maternal (p = 0.000; p = 0.017) and foetal (p = 0.009; p = 0.002), and maternal erucic acid (C22:1, n-9; p = 0.026) were found at higher levels in SGA infants as compared to AGA ones. Conversely, maternal LA, AA, and omega 6 FAs levels were higher in AGA infants (p = 0.037; p = 0.003; p = 0.026, respectively). Maternal and foetal polyunsaturated and omega 6 FAs levels are positively related to BW, while a lipid profile rich in saturated FAs and erucic acid may influence the risk of SGA.
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影响因子：
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作者：
Osmond C;Barker DJ
通讯作者：
Barker DJ
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作者：
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