Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance.
Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance.
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DOI：
10.1111/j.1574-6976.2011.00284.x
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发表时间：
2011-09
影响因子：
11.3
通讯作者：
Feil EJ
中科院分区：
文献类型：
--
作者：
Willems RJ;Hanage WP;Bessen DE;Feil EJ
多重耐药革兰氏阳性菌引起的感染是社区和住院患者的主要健康负担。金黄色葡萄球菌、粪肠球菌和屎肠球菌是住院患者的常见病原体，通常与对多种抗生素的耐药性有关，影响有效治疗。肺炎链球菌和化脓性链球菌是该社区的重要病原菌，链球菌。金黄色葡萄球菌最近已成为重要的社区获得性病原体。群体遗传学研究表明，重组是E.屎肠球菌E. faecalis、S. pneumoniae和S.因此，这些物种是弱克隆的。尽管重组在驱动S.金黄色葡萄球菌中，抗性和毒力基因的水平获得在该物种中新的临床相关克隆的出现中起关键作用。本文对E.屎肠球菌E. faecalis、S.肺炎链球菌（S.化脓性链球菌和S.金黄色。这些病原体的种群结构的知识不仅是高度相关的（分子）流行病学研究，但也为确定遗传变异的临床行为的变化，以提高我们的理解特定克隆的致病行为，并确定新的疫苗或免疫治疗的目标。
Infections caused by multi-resistant Gram positive bacteria represent a major health burden in the community as well as in hospitalized patients. Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium are well-known pathogens of hospitalized patients, frequently linked with resistance against multiple antibiotics, compromising effective therapy. Streptococcus pneumoniae and Streptococcus pyogenes are important pathogens in the community and S. aureus has recently emerged as an important community-acquired pathogen. Population genetic studies reveal that recombination prevails as a driving force of genetic diversity in E. faecium, E. faecalis, S. pneumoniae, and S. pyogenes and thus, these species are weakly clonal. Although recombination has a relatively modest role driving the genetic variation of the core genome of S. aureus, the horizontal acquistion of resistance and virulence genes plays a key role in the emergence of new clinically relevant clones in this species. In this review we discuss the population genetics of E. faecium, E. faecalis, S. pneumoniae, S. pyogenes, and S. aureus. Knowledge of the population structure of these pathogens is not only highly relevant for (molecular) epidemiological research but also for identifying the genetic variation that underlies changes in clinical behaviour, to improve our understanding of the pathogenic behaviour of particular clones and to identify novel targets for vaccines or immunotherapy.
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影响因子：
3.2
作者：
Aanensen, David M.;Mavroldi, Angeliki;Spratt, Brian G.
通讯作者：
Spratt, Brian G.
影响因子：
6.4
作者：
Beall, Bernard W.;Gertz, Robert E.;Brueggemann, Angela B.
通讯作者：
Brueggemann, Angela B.
影响因子：
3.6
作者：
Black, S;Shinefield, H;Edwards, K
通讯作者：
Edwards, K
影响因子：
3.4
作者：
BARBER, M
通讯作者：
BARBER, M
影响因子：
3.7
作者：
Beres SB;Musser JM
通讯作者：
Musser JM