Molecular surveillance of traditional and emerging pathogens associated with canine infectious respiratory disease.
Molecular surveillance of traditional and emerging pathogens associated with canine infectious respiratory disease.
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DOI：
10.1016/j.vetmic.2016.06.009
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发表时间：
2016-08-30
影响因子：
3.3
通讯作者：
Buonavoglia C
中科院分区：
文献类型：
--
作者：
Decaro N;Mari V;Larocca V;Losurdo M;Lanave G;Lucente MS;Corrente M;Catella C;Bo S;Elia G;Torre G;Grandolfo E;Martella V;Buonavoglia C
在2011-2013年期间对CIRD试剂进行了分子调查。犬副流感病毒是最常见的病原体。新出现的病原体犬呼吸道冠状病毒、犬支原体和犬肺炎病毒零星检出。大多数严重形式的呼吸道疾病在感染M. cynos单独或与CRCoV或M.犬。CIRD疫苗应更新，以包括新出现的病原体。2011年至2013年期间，在意大利对共计138只犬进行了犬传染性呼吸道疾病（CIRD）相关传统和新兴病原体的分子调查，其中包括78只早期急性临床疾病CIRD动物、22只非临床但暴露于临床疾病CIRD犬和38只CIRD恢复期犬。结果表明，犬副流感病毒（CPIV）是最常见的CIRD病原，其次是犬呼吸道冠状病毒（CRCoV）、支气管败血波氏杆菌、犬支原体、犬支原体和犬肺炎病毒（CnPnV）。一些经典的CIRD病原体，如犬腺病毒、犬瘟热病毒和犬科疱疹病毒1型，根本没有检测到，其他新兴的呼吸道病毒（犬流感病毒、犬肝炎病毒）和细菌（马链球菌亚种）也没有检测到。动物寄生虫）。在存在CPIV、CRCoV和M的情况下观察到最严重形式的呼吸道疾病。cynos单独或与其他病原体组合，而单独CnPnV或M.在没有呼吸道症状或呼吸道症状非常轻微的犬中检测到犬感染。有趣的是，只有M. cynos（单独或与CRCoV或M.犬）与严重临床形式的差异有统计学意义。该研究在确认CPIV是CIRD发生的主要原因的同时，强调了最近发现的病毒（如CRCoV和CnPnV）的作用越来越大，市场上没有有效的疫苗。
A molecular survey for CIRD agents was conducted during years 2011–2013. Canine parainfluenza virus was the most frequently detected pathogens. The emerging pathogens canine respiratory coronavirus, Mycoplasma cynos and canine pneumovirus were sporadically detected. Most severe forms of respiratory disease were observed in dogs infected with M. cynos alone or in combination with either CRCoV or M. canis. CIRD vaccines should be updated to include emerging pathogens. A molecular survey for traditional and emerging pathogens associated with canine infectious respiratory disease (CIRD) was conducted in Italy between 2011 and 2013 on a total of 138 dogs, including 78 early acute clinically ill CIRD animals, 22 non-clinical but exposed to clinically ill CIRD dogs and 38 CIRD convalescent dogs. The results showed that canine parainfluenza virus (CPIV) was the most commonly detected CIRD pathogen, followed by canine respiratory coronavirus (CRCoV), Bordetella bronchiseptica, Mycoplasma cynos, Mycoplasma canis and canine pneumovirus (CnPnV). Some classical CIRD agents, such as canine adenoviruses, canine distemper virus and canid herpesvirus 1, were not detected at all, as were not other emerging respiratory viruses (canine influenza virus, canine hepacivirus) and bacteria (Streptococcus equi subsp. zooepidemicus). Most severe forms of respiratory disease were observed in the presence of CPIV, CRCoV and M. cynos alone or in combination with other pathogens, whereas single CnPnV or M. canis infections were detected in dogs with no or very mild respiratory signs. Interestingly, only the association of M. cynos (alone or in combination with either CRCoV or M. canis) with severe clinical forms was statistically significant. The study, while confirming CPIV as the main responsible for CIRD occurrence, highlights the increasing role of recently discovered viruses, such as CRCoV and CnPnV, for which effective vaccines are not available in the market.
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影响因子：
3.1
作者：
Dowgier, Giulia;Mari, Viviana;Decaro, Nicola
通讯作者：
Decaro, Nicola
DOI：
10.1111/jsap.12431
发表时间：
2016-01-01
期刊：
The Journal of small animal practice
影响因子：
--
作者：
Day, M J;Horzinek, M C;Squires, R A
通讯作者：
Squires, R A
影响因子：
1.2
作者：
Mochizuki, Masami;Yachi, Akiko;Ishida, Takuo
通讯作者：
Ishida, Takuo
影响因子：
3.7
作者：
El-Attar, L. M. R.;Mitchell, J. A.;Brownlie, J.
通讯作者：
Brownlie, J.
影响因子：
3.1
作者：
Elia, Gabriella;Decaro, Nicola;Buonavoglia, Canio
通讯作者：
Buonavoglia, Canio