Prenatal cocaine exposure and infant cortisol reactivity.

Prenatal cocaine exposure and infant cortisol reactivity.
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产前可卡因暴露和婴儿皮质醇反应性。

DOI:
10.1111/j.1467-8624.2009.01277.x
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发表时间:
2009-03
期刊:
影响因子:
4.6
通讯作者:
Granger, Douglas A.
Granger, Douglas A.
中科院分区:
心理学1区
文献类型:
--
作者:
Eiden, Rina D.;Veira, Yvette;Granger, Douglas A.

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本研究探讨了产前可卡因暴露对婴儿下丘脑-垂体-肾上腺轴活动和7个月龄婴儿反应性的影响。参与者为168名婴儿-婴儿二对(87名接触可卡因,81名未接触可卡因; 47%为男孩)。母亲的行为,分娩不稳定性,婴儿的生长和行为进行了评估,儿童的唾液采样之前,期间和之后的标准化程序,旨在引起情绪的唤起。结果显示,可卡因暴露的婴儿有一个高幅度的皮质醇反应轨迹相比,非可卡因暴露的婴儿。婴儿性别和生育不稳定调节了这种关联。研究结果支持一个双重危险的脆弱性模型,并对生物敏感性的个体差异的进化发展理论的背景。
This study examined the effects of prenatal cocaine exposure on infant hypothalamic-pituitary-adrenal axis activity and reactivity at 7 months of infant age. Participants were 168 caregiver-infant dyads (87 cocaine exposed, 81 not cocaine exposed; 47% boys). Maternal behavior, caregiving instability, and infant growth and behavior were assessed, and children's saliva was sampled before, during, and after standardized procedures designed to elicit emotional arousal. Results revealed cocaine-exposed infants had a high amplitude trajectory of cortisol reactivity compared to non-cocaine-exposed infants. Infant gender and caregiving instability moderated this association. The findings support a dual hazard vulnerability model and have implications for evolutionary-developmental theories of individual differences in biological sensitivity to context.
DOI: 10.1016/j.ntt.2004.10.004
发表时间: 2005-03-01
影响因子: 2.9
作者:
Bailey, BN;Sood, BG;Delaney-Black, V
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